Differential activation of glutamate receptor subtypes on a single class of cells enables a neural oscillator to produce distinct behaviors.
Differential activation of glutamate receptor subtypes on a single class of cells enables a neural oscillator to produce distinct behaviors.
复制标题
一类细胞上谷氨酸受体亚型的差异激活使神经振荡器能够产生不同的行为。
DOI：
10.1152/jn.1997.78.2.835
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
Spiro,JE
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作者：
Spiro,JE
Spiro，John E.单类细胞上谷氨酸受体亚型的差异激活使神经振荡器产生不同的行为。神经生理学杂志78：835-847，1997。电鱼产生不同类型的突然调制其电器官放电（EOD）的节奏，以传达特定的社会信号。细胞内的记录，从神经元的延髓起搏器核，产生和传输的节奏，驱动EOD，研究两个这样的调制规律的EOD节奏，突然加速，突然中断的神经元基础。记录都在体内，并在一个新的体外脑制备的Hypopomus pinnicaudatus（目的Gymnotiformes）。触发行为过程中的体内记录表明，EOD节律的突然调制产生于延髓起搏核的中继细胞水平，中继细胞是核的投射细胞，而不是起搏细胞。在体外脑干制备中，起搏核的细胞自发地和有节奏地活跃，如在完整的动物中一样。起搏核节律的独特调制与自然行为中所见的非常相似，可以通过电刺激传入纤维来触发。节律的调节也可以通过中继细胞的直接药理学激活来触发。当非N-甲基-d-天冬氨酸（NMDA）受体被激活时，中继细胞瞬时去极化并产生同步动作电位的爆发。NMDA受体激活，或者，启动了一个延长的去极化的中继细胞，在此期间，他们未能中继规则的起搏器节奏。继电器单元的两种点火状态与爆炸物处理的突然加速和突然中断直接相关。
Spiro, John E.Differential activation of glutamate receptor subtypes on a single class of cells enables a neural oscillator to produce distinct behaviors.J. Neurophysiol.78: 835–847, 1997. Electric fish generate different types of abrupt modulations of their electric organ discharge (EOD) rhythm to convey specific social signals. Intracellular recordings were made from neurons of the medullary pacemaker nucleus, which generates and transmits the rhythm that drives the EOD, to study the neuronal basis of two such modulations of the regular EOD rhythm, sudden accelerations, and abrupt interruptions. Recordings were both in vivo, and in a new in vitro brain preparation ofHypopomus pinnicaudatus(order Gymnotiformes). In vivo recordings during triggered behaviors indicated that abrupt modulations of the EOD rhythm are generated in the medullary pacemaker nucleus at the level of the relay cells, which are the projection cells of the nucleus, and not the pacemaker cells. In the in vitro brain stem preparation, cells of the pacemaker nucleus were spontaneously and rhythmically active as in the intact animal. Distinct modulations of the pacemaker nucleus rhythm that closely resembled those seen during natural behaviors could be triggered by electrical stimulation of afferent fibers. Modulations of the rhythm also could be triggered by direct pharmacological activation of the relay cells. When non-N-methyl-d-aspartate (NMDA) receptors were activated, relay cells were transiently depolarized and generated bursts of synchronized action potentials. NMDA receptor activation, alternatively, initiated a prolonged depolarization in the relay cells, during which time they failedto relay the regular pacemaker rhythm. The two firing states ofthe relay cell directly correlate with sudden accelerations and abrupt interruptions of the EOD.