Immunity to tetanus, diphtheria and poliomyelitis in the adult population of Sweden in 1991
Immunity to tetanus, diphtheria and poliomyelitis in the adult population of Sweden in 1991
复制标题
DOI：
10.1093/ije/27.5.916
复制
发表时间：
1998-10-01
影响因子：
7.7
通讯作者：
Svensson, Å
中科院分区：
文献类型：
--
作者：
Böttiger, M;Gustavsson, E;Svensson, Å
背景 1990 年和 1991 年，瑞典进行了一项免疫力调查。主要目的是估计成年人口对白喉、破伤风和脊髓灰质炎的免疫力水平。根据分层、两阶段抽样计划，总共联系了 4800 人，并要求他们提供血样。在被选择的人中，70.6% 提供了血液样本。方法计算了抗体超过一定滴度的人群比例的估计值和置信区间。根据性别、出生年份（五个年龄组）和居住地（四个地区）对人群进行划分。 结果 在引入儿童疫苗接种后出生的年龄组中，大于或等于 90% 和 75-90% 的人分别具有针对破伤风和白喉的保护性抗体水平。较早出生的人，尤其是女性，保护很差，不到 50% 的人具有针对破伤风和白喉的保护性抗体水平。男性和女性之间的差异在 1930 年至 1950 年间出生的年龄组中尤为明显。不到 5% 的瑞典人口分别缺乏针对 1 型、2 型和 3 型脊髓灰质炎的保护水平抗体。结论 破伤风疫苗接种可与白喉疫苗接种联合使用，特别适合 1950 年之前出生且之前没有疫苗接种记录的女性。同样的建议也适用于 20 世纪 30 年代之前出生的男性。至于脊髓灰质炎，目前似乎没有必要对成年人进行全面加强疫苗接种。
Background During 1990 and 1991 a survey of immunity was carried out in Sweden. The main purpose was to estimate the level of immunity to diphtheria, tetanus and polio in the adult population. In total, 4800 people, randomly selected according to a stratified, two-stage, sampling plan, were contacted and asked to contribute a blood sample. Of those selected, 70.6% gave a blood sample.Methods Estimates and confidence intervals of the proportion of the population with antibodies exceeding some titre was calculated. The population was divided according to sex, year of birth (five age groups) and residence (four regions).Results In age groups that were born after the introduction of childhood vaccination, greater than or equal to 90% and 75-90% of people have demonstrable antibodies at a protective level against tetanus and diphtheria respectively Those born earlier, especially women, are poorly protected with less than 50% having protective antibody levels for both tetanus and diphtheria. Differences between men and women were particularly seen in the age groups born between 1930 and 1950. Less than 5% of the Swedish population lacked the protective level antibodies against polio types 1, 2 and 3 respectively.Conclusions Vaccination against tetanus, which can be combined with vaccination against diphtheria, can be recommended especially to women born before 1950 and with no documented previous vaccination. The same recommendation can be given for men born before the 1930s. As regards poliomyelitis, general booster vaccination of the adult population does not appear to be necessary at present.