Synthesis, properties and in vitro degradation of carboxyl-bearing PCL
Synthesis, properties and in vitro degradation of carboxyl-bearing PCL
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DOI：
10.1106/mf92-tcjc-kc2x-j0fb
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发表时间：
2001-01-01
影响因子：
1.7
通讯作者：
Vert, M
中科院分区：
文献类型：
--
作者：
Gimenez, S;Ponsart, S;Vert, M
由乳酸和乙醇酸衍生的脂肪族聚酯 (PLAGA) 是在生物医学和环境应用方面最具吸引力的可降解聚合物。聚(ε-己内酯)，PCL，是一种疏水性高结晶脂肪族聚酯，比 PLA 更耐水解降解。它在动物体内不可生物降解，但会被室外微生物迅速降解。为了提高材料的水解速率，通过LDA阴离子活化和CO2在聚碳负离子上的反应合成了含羧基的PCL共聚物(PCLCOOH)。研究了侧羧基的存在引起的结晶度、热性能和亲水性的变化。通过评估吸水率、质量损失、分子量和 ESEM 显微照片来评估 PCLCOOH 的降解行为。与纯PCL相比，观察到水解降解率显着增加，因此PCLCOOH现在可以被认为是一种可水解降解的聚合物。
Aliphatic polyesters derived from lactic and glycolic acids (PLAGA) are the most attractive degradable polymers with respect to biomedical and environmental applications.Poly(-epsilon -caprolactone), PCL, is a hydrophobic highly crystalline aliphatic polyester that is more resistant to hydrolytic degradation than PLA. It is not biodegradable in animal body but is rapidly degraded by outdoor microorganisms. In order to increase the rate of hydrolysis of the material, carboxyl-bearing PCL copolymers (PCLCOOH) were synthesized by anionic activation with LDA and reaction of CO2 on the polycarbanion. Variations in crystallinity, thermal properties and hydrophilicity caused by the presence of the pendent carboxyl groups were investigated. The degradation behavior of PCLCOOH was assessed by the evaluation of water uptake, mass loss, molecular masses and ESEM microphotographs. A dramatic increase in the hydrolytic degradation rate was observed compared with pure PCL, thus PCLCOOH can now be considered as a hydrolytically degradable polymer.