Coronary stent thrombosis related to aspirin resistance: what are the underlying mechanisms?
Coronary stent thrombosis related to aspirin resistance: what are the underlying mechanisms?
复制标题
DOI：
10.1111/j.1540-8183.2006.00196.x
复制
发表时间：
2006-12-01
影响因子：
2.1
通讯作者：
Kranzhofer, Roger
中科院分区：
文献类型：
--
作者：
Ruef, Johannes;Kranzhofer, Roger
急性冠状动脉支架血栓形成是一种严重的并发症，阿司匹林耐药性可能是其潜在原因。实际病例为心肌梗死患者，立即行右冠状动脉支架置入术，4天后择期行左前降支支架置入术。尽管标准的抗血小板治疗，在最后一次手术后2天，两条动脉的支架闭塞。对患者的血液样本进行了分析，发现存在阿司匹林抵抗以及血栓素B(2)血浆水平升高。未发现血栓性疾病。今天，阿司匹林耐药的机制大多是未知的。需要进一步的研究以及实验室筛查和替代药物治疗方案的建议。
Acute coronary stent thrombosis represents a serious complication for which aspirin resistance could be a potential cause. The actual case is a myocardial infarction treated with immediate stenting of the right coronary artery followed by elective stenting of the left anterior descending artery 4 days later. Despite standard antiplatelet therapy, stents in both arteries occluded 2 days after the last procedure. The patient's blood samples were analyzed and revealed the presence of aspirin resistance as well as elevated thromboxane B(2) plasma levels. No thrombophilic disorder was detected. Today the mechanism of aspirin resistance is mostly unknown. Further research as well as recommendations for laboratory screening and for alternative pharmacological treatment options are required.