Relationship of sarcopenia and body composition with osteoporosis
Relationship of sarcopenia and body composition with osteoporosis
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DOI：
10.1007/s00198-015-3241-8
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发表时间：
2016-02-01
影响因子：
4
通讯作者：
Deng, H. -W.
中科院分区：
文献类型：
--
作者：
He, H.;Liu, Y.;Deng, H. -W.
该研究的目的是调查三个不同种族共17，891名受试者的骨骼肌减少症与身体成分和骨质疏松症之间的关系。瘦体重和握力与骨密度（BMD）呈正相关。与肌肉减少症的主题是两倍更容易患骨质疏松症相比，正常subjects.Introduction肌肉减少症和骨质疏松症之间的关系是不完全清楚。首先，本研究通过使用两种不同的肌肉减少症定义来评估这种关系。其次，我们研究了身体成分（包括肌肉质量作为一个主要和重要的组成部分）和肌肉力量对区域和全身BMDs.Methods的协会，共17,891名受试者的非洲裔美国人，高加索人和中国种族进行了分析。通过相对非典型骨骼肌质量（RASM）临界点以及欧洲老年人肌肉减少症工作组的定义（低RASM加低肌肉功能）定义肌肉减少症。进行多元回归分析，以检查脂肪质量，瘦体重（包括肌肉质量），和握力与区域和全身BMD的关联。多因素Logistic回归分析探讨肌肉减少症和骨量减少/骨质疏松症之间的关系。结果在控制潜在混杂因素后，BMD与瘦体重呈正相关，与脂肪量呈负相关。握力与较高的BMD显著相关。RASM的每个标准差（SD）增加导致骨质减少/骨质疏松症风险降低37%（比值比（OR）= 0.63; 95%置信区间（CI）= 0.59，0.66）。RASM定义的肌肉减少症患者发生骨量减少/骨质疏松的可能性是正常人的2倍（OR = 2.04; 95% CI = 1.61，2.60）。骨骼肌减少症（低肌肉质量和低握力）患者发生骨质减少/骨质疏松的可能性是正常人的1.8倍（OR = 1.87，95%CI = 1.09，3.20）。肌肉减少症与低BMD和骨质疏松症有关。
The purpose of the study is to investigate the relationship between sarcopenia and body composition and osteoporosis in cohorts of three different races with a total of 17,891 subjects. Lean mass and grip strength were positively associated with bone mineral densities (BMDs). Subjects with sarcopenia were two times more likely to have osteoporosis compared with normal subjects.Introduction The relationship between sarcopenia and osteoporosis is not totally clear. First, the present study assessed this relationship by using two different definitions for sarcopenia. Second, we examined the associations of body composition (including muscle mass as a major and important component) and muscle strength on regional and whole-body BMDs.Methods In total, 17,891 subjects of African American, Caucasian, and Chinese ethnicities were analyzed. Sarcopenia was defined by relative appendicular skeletal muscle mass (RASM) cut points and also by the definition of the European Working Group on Sarcopenia in Older People (low RASM plus low muscle function). Multiple regression analyses were conducted to examine the association of fat mass, lean mass (including muscle mass), and grip strength with regional and whole-body BMDs. Multivariate logistic regression analysis was performed to explore the association between sarcopenia and osteopenia/osteoporosis.Results BMDs were positively associated with lean mass and negatively associated with fat mass, after controlling for potential confounders. Grip strength was significantly associated with higher BMDs. Each standard deviation (SD) increase in RASM resulted in a similar to 37 % reduction in risk of osteopenia/osteoporosis (odds ratio (OR) = 0.63; 95 % confidence interval (CI) = 0.59, 0.66). Subjects with sarcopenia defined by RASM were two times more likely to have osteopenia/osteoporosis compared with the normal subjects (OR = 2.04; 95 % CI = 1.61, 2.60). Similarly, subjects with sarcopenia (low muscle mass and low grip strength) were similar to 1.8 times more likely to have osteopenia/osteoporosis than normal subjects (OR = 1.87; 95 % CI = 1.09, 3.20).Conclusions High lean mass and muscle strength were positively associated with BMDs. Sarcopenia is associated with low BMD and osteoporosis.