Trehalose rescues Alzheimer's disease phenotypes in APP/PS1 transgenic mice
Trehalose rescues Alzheimer's disease phenotypes in APP/PS1 transgenic mice
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DOI：
10.1111/jphp.12108
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发表时间：
2013-12-01
影响因子：
3.3
通讯作者：
Wang, Zhao
中科院分区：
文献类型：
--
作者：
Du, Jing;Liang, Yu;Wang, Zhao
阿尔茨海默病（Alzheimer's Disease，AD）是一种以海马和大脑皮层A斑的积累为特征的疾病，伴随着学习和学习能力的显著降低。海藻糖是一种天然二糖，已被证明具有神经保护特性，并在几种神经退行性疾病的动物模型中表现出治疗作用。然而，海藻糖对AD病理学的影响在很大程度上仍然未知。MethodsIn this study，我们通过行为测试和生化分析评估了海藻糖在APP/PS1转基因小鼠中的作用。Key findingsWe发现，受损的认知和学习能力得到改善，海马存款减少。
ObjectiveAlzheimer's Disease (AD) is well characterized by the accumulated A plaque in hippocampus and cerebral cortex concomitant with markedly reduced study and learning ability. Trehalose, a natural disaccharide, has been shown to have neural protective properties and exhibited therapeutic effects in animal models of several neural degenerative disorders. However, the effect of trehalose on AD pathology remains largely unknown.MethodsIn this study, we evaluated the effects of trehalose in APP/PS1 transgenic mice through behaviour tests and biochemical analyses.Key findingsWe found that the impaired cognitive and learning ability was improved and A deposit in hippocampus was reduced.ConclusionsThese results suggested that trehalose could be a potential therapeutic drug for the treatment of AD.