Favorable Venous Outflow Profiles Correlate With Favorable Tissue-Level Collaterals and Clinical Outcome
Favorable Venous Outflow Profiles Correlate With Favorable Tissue-Level Collaterals and Clinical Outcome
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DOI：
10.1161/strokeaha.120.032242
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发表时间：
2021-05-01
期刊：
影响因子：
8.3
通讯作者：
Heit, Jeremy J.
中科院分区：
文献类型：
--
作者：
Faizy, Tobias D.;Kabiri, Reza;Heit, Jeremy J.
背景和目的：由于大血管闭塞和良好的组织水平侧支（TLCs）导致的急性缺血性卒中患者可能有强大的皮质静脉流出（VO）。我们假设良好的VO预示着强大的TLC和良好的临床结果。方法：多中心回顾性队列研究大血管闭塞致急性缺血性脑卒中患者行取栓分诊。纳入的患者进行了可解释的血栓切除术前计算机断层扫描、计算机断层血管成像和脑灌注成像。TLCs在脑灌注研究中采用低灌注强度比（脑组织体积比[Tmax >10 s/Tmax >6 s]）测量。ct血管造影示Labbe静脉、蝶顶窦、大脑浅层中静脉混浊为0，不可见；1、混浊适度；2是满的。临床和人口统计数据由电子病历确定。使用多变量回归分析，我们确定了VO与(1)有利的TLC状态（定义为低灌注强度比）之间的关联
Background and Purpose:Patients with acute ischemic stroke due to large vessel occlusion and favorable tissue-level collaterals (TLCs) likely have robust cortical venous outflow (VO). We hypothesized that favorable VO predicts robust TLC and good clinical outcomes.Methods:Multicenter retrospective cohort study of consecutive acute ischemic stroke due to large vessel occlusion patients who underwent thrombectomy triage. Included patients had interpretable prethrombectomy computed tomography, computed tomography angiography, and cerebral perfusion imaging. TLCs were measured on cerebral perfusion studies using the hypoperfusion intensity ratio (volume ratio of brain tissue with [Tmax >10 s/Tmax >6 s]). VO was determined by opacification of the vein of Labbe, sphenoparietal sinus, and superficial middle cerebral vein on computed tomography angiography as 0, not visible; 1, moderate opacification; and 2, full. Clinical and demographic data were determined from the electronic medical record. Using multivariable regression analyses, we determined the association between VO and (1) favorable TLC status (defined as hypoperfusion intensity ratio