A practical new way to measure kidney fibrosis.
A practical new way to measure kidney fibrosis.
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一种测量肾纤维化的实用新方法。
DOI：
10.1016/j.kint.2016.07.036
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发表时间：
2016
影响因子：
19.6
通讯作者：
Peti-Peterdi,János
中科院分区：
文献类型：
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作者：
Peti-Peterdi,János
肾脏纤维化的适当组织学测量在临床病理学和使用慢性肾脏病（CKD）动物模型的基础研究中都是至关重要的。然而，标准的组织学技术及其盲法评价是繁琐的。Ranjitet等人应用了一种先进的光学显微镜技术，用于无障碍、无偏见和高度灵敏的肾纤维化表征，并在小鼠慢性肾脏疾病的经典模型中进行了测试。这篇评论强调了这种新方法的优点和未来的希望。
Proper histological measurement of kidney fibrosis is essentially important in both clinical pathology and basic research using animal models of chronic kidney disease (CKD). However, standard histology techniques and their blind evaluation are cumbersome. Ranjitet al.applied an advanced optical microscopy technique for hassle-free, unbiased, and highly sensitive characterization of kidney fibrosis and tested it in a classic model of chronic kidney disease in mice. This commentary emphasizes the advantages and future promise of this new approach.