Disseminated Mycobacterium avium-intracellulare infection in homosexual men with acquired cell-mediated immunodeficiency: a histologic and immunologic study of two cases.
Disseminated Mycobacterium avium-intracellulare infection in homosexual men with acquired cell-mediated immunodeficiency: a histologic and immunologic study of two cases.
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患有获得性细胞介导免疫缺陷的同性恋男性中传播的鸟胞内分枝杆菌感染：两例病例的组织学和免疫学研究。
DOI：
10.1093/ajcp/79.2.247
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发表时间：
1983
影响因子：
3.5
通讯作者：
Fligiel,S
中科院分区：
文献类型：
--
作者：
Sohn,CC;Schroff,RW;Kliewer,KE;Lebel,DM;Fligiel,S
尸检时在两名同性恋男子身上发现了播散性鸟分枝杆菌细胞内感染，对这两名男子的获得性细胞介导的免疫缺陷和表达 T 辅助表型的淋巴细胞亚群的显着减少进行了深入研究。其组织学表现与瘤性麻风病相似，也已知与细胞介导的免疫缺陷有关。我们对患者的细胞免疫缺陷与鸟分枝杆菌细胞内感染易感性增加以及分枝杆菌感染的异常组织学表现之间可能存在的相关性进行了检查。
DisseminatedMycobacterium avium-intracellulareinfections were found at autopsy in two homosexual men in whom acquired cell-mediated immunodeficiencies and marked decreases in the subpopulation of lymphocytes expressing the T-helper phenotype were well-studied. The histologic manifestations were similar to those found in lepromatous leprosy, also known to be associated with cell-mediated immunodeficiency. Possible correlations between the cellular immunodeficiency in our patients and an increased susceptibility toMycobacterium avium-intracellulareinfection as well as the unusual histologic manifestation of the mycobacterial infection are examined.