Unstable representation of sound: a biological marker of dyslexia.
Unstable representation of sound: a biological marker of dyslexia.
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DOI：
10.1523/jneurosci.4205-12.2013
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发表时间：
2013-02-20
期刊：
影响因子：
--
通讯作者：
Kraus N
中科院分区：
文献类型：
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作者：
Hornickel J;Kraus N
对大多数孩子来说，学习阅读进展顺利，但有些孩子却很难将口头语言转化为书面形式。阅读能力差的人通常有听觉、语言和注意力缺陷，包括言语的异常神经表征和心理声学任务的不一致表现。我们假设，这些与阅读相关的缺陷是由于人类听觉系统不能以一致的方式对声音做出反应，而这种不一致影响了阅读过程中将音韵学和正字法联系起来的能力。为了支持这一假设，我们发现阅读能力差的人对语音的听觉脑干反应明显比阅读能力好的人更多，这与静息神经生理噪音水平无关。因此，神经变异可能是在阅读能力差的人身上发现的行为和神经缺陷的潜在生物学因素。
Learning to read proceeds smoothly for most children, yet others struggle to translate verbal language into its written form. Poor readers often have a host of auditory, linguistic, and attention deficits, including abnormal neural representation of speech and inconsistent performance on psychoacoustic tasks. We hypothesize that this constellation of reading-related deficits arises from the human auditory system failing to respond to sound in a consistent manner, and that this inconsistency impinges upon the ability to relate phonology and orthography during reading. In support of this hypothesis, we show that poor readers have significantly more variable auditory brainstem responses to speech than do good readers, independent of resting neurophysiological noise levels. Thus, neural variability may be an underlying biological contributor to well-established behavioral and neural deficits found in poor readers.