Ketamine and Lornoxicam for Preventing a Fentanyl-Induced Increase in Postoperative Morphine Requirement
Ketamine and Lornoxicam for Preventing a Fentanyl-Induced Increase in Postoperative Morphine Requirement
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氯胺酮和氯诺昔康用于预防芬太尼引起的术后吗啡需求增加
DOI：
10.1213/ane.0b013e3181888061
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发表时间：
2008-12
影响因子：
5.7
通讯作者：
Yuguang Huang
中科院分区：
文献类型：
--
作者：
Xuerong Yu;Yuguang Huang
BACKGROUND:N-methyl-d-aspartate receptor antagonists and nonsteroidal anti-inflammatory drugs are believed to prevent opioid-induced hyperalgesia and/or acute opioid tolerance, which could cause an increase in postoperative opioid requirement. In this randomized, double-blind, placebo-controlled study, we investigated whether co-administration of ketamine or lornoxicam and fentanyl could prevent the increase of postoperative morphine requirement induced by fentanyl alone. METHODS:Ninety females undergoing total abdominal hysterectomy with spinal anesthesia were randomly assigned to six groups consisting of placebo (normal saline, C), fentanyl (three bolus of 1 &mgr;g · kg−1, F), ketamine (infusion of 15 &mgr;g · kg−1 · min−1, K), ketamine and fentanyl (infusion of 15 &mgr;g · kg−1 · min−1 ketamine plus three bolus of 1 &mgr;g · kg−1 fentanyl, FK), lornoxicam (one bolus of 8 mg, L), and lornoxicam and fentanyl (one bolus of 8 mg lornoxicam plus three bolus of 1 &mgr;g · kg−1 fentanyl, FL). Cumulative morphine consumption, pain score, and adverse effects were recorded at 1, 3, 6, 12, 24, and 48 h postoperatively. RESULTS:Cumulative morphine consumption in Group F was significantly more than that in Group C at 3, 6, and 12 h postoperatively (P < 0.05). Postoperative cumulative morphine consumption was similar in Groups C, K, FK, L, and FL. No differences in postoperative pain scores were observed among groups. More patients in Groups K and FK had hallucinations during and/or after surgery than those in Group C (P < 0.05). CONCLUSIONS:Our data suggest that the increase of postoperative morphine requirements induced by intraoperative administration of fentanyl could be prevented by ketamine or lornoxicam.
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影响因子：
8.8
作者：
A. Tröster;R. Sittl;B. Singler;M. Schmelz;J. Schüttler;W. Koppert
通讯作者：
A. Tröster;R. Sittl;B. Singler;M. Schmelz;J. Schüttler;W. Koppert
影响因子：
8.8
作者：
Guignard, B;Bossard, AE;Chauvin, M
通讯作者：
Chauvin, M
影响因子：
7.4
作者：
De Kock, M;Lavand'homme, P;Waterloos, H
通讯作者：
Waterloos, H
影响因子：
5.7
作者：
Kissin, I;Bright, CA;Bradley, EL
通讯作者：
Bradley, EL
DOI：
10.1007/bf03013041
发表时间：
1996-08
期刊：
Canadian Journal of Anesthesia/Journal canadien d'anesthésie
影响因子：
--
作者：
W. Parris;Piotr K. Janicki;Benjamin W. Johnson;Jean-Louis Horn
通讯作者：
W. Parris;Piotr K. Janicki;Benjamin W. Johnson;Jean-Louis Horn