May there exist specific MRI findings predictive of dementia in multiple sclerosis patients?
May there exist specific MRI findings predictive of dementia in multiple sclerosis patients?
复制标题
是否存在可预测多发性硬化症患者痴呆的特定 MRI 结果？
作者：
F. Patti;M. Di Stefano;D. de Pascalis;M. Ciancio;E. de Bernardis;F. Nicoletti;A. Reggio
认知缺陷存在于大量的多发性硬化症（MS）患者中，特别是那些患有慢性进展型疾病的患者。我们评估了认知功能下降及其与磁共振成像（MRI）T2加权图像的关系。我们提交了一组26例进行性MS患者的MRI和神经心理学测试电池。认知功能障碍与病程或神经功能障碍的严重程度无关，但与MRI上广泛的脑室周围脱髓鞘（评估为融合性病变区域）的存在相关。这些结果表明，MS中的认知缺陷代表疾病的症状，而不是平行发生。
Cognitive deficits are present in a substantial number of Multiple Sclerosis (MS) patients, particularly in those with the chronic-progressive type of the disorder. We assessed cognitive decline and its relationship with T2-weighted images on magnetic resonance imaging (MRI). We submitted a group of 26 patients with progressive MS to both MRI and a battery of neuropsychological tests. Cognitive impairment did not correlate with duration of illness or severity of neurological disability, but rather with the presence of extensive periventricular demyelination on MRI, evaluated as area of confluent lesions. These results suggest that cognitive deficits in MS represent a symptom of disease and not a parallel occurrence.