Early life adversities or high fat diet intake reduce cognitive function and alter BDNF signaling in adult rats: Interplay of these factors changes these effects
Early life adversities or high fat diet intake reduce cognitive function and alter BDNF signaling in adult rats: Interplay of these factors changes these effects
复制标题
DOI：
10.1016/j.ijdevneu.2016.03.001
复制
发表时间：
2016-05-01
影响因子：
1.8
通讯作者：
Dalmaz, Carla
中科院分区：
文献类型：
--
作者：
Arcego, Danusa Mar;Krolow, Rachel;Dalmaz, Carla
环境因素，如早期暴露于压力源或高热量饮食，可以改变中枢神经系统的早期编程，导致对认知功能的长期影响，增加认知能力下降的脆弱性，并在以后的生活中发展为精神病理学。这些因素之间的相互作用及其对大脑结构和功能的综合影响仍然没有完全了解。在这项研究中，我们评估了在青春期前的社会隔离的长期影响，有或没有慢性高脂肪饮食的访问，对记忆和大鼠前额叶皮层的神经化学标志物。我们观察到，早期社会隔离导致成年期短期记忆和工作记忆的损害，以及前额叶皮层Na+，K+-ATP酶活性和磷酸化AKT的免疫含量的降低。长期接触高脂肪饮食会损害短期记忆（物体识别），并降低同一大脑区域的BDNF水平。值得注意的是，社会隔离与慢性高脂肪饮食的关联挽救了物体识别测试中的记忆障碍，以及BDNF水平、Na+，K+-ATP酶活性、MAPK、AKT和磷酸化AKT的变化，达到与对照组相似的水平。总之，这些研究结果表明，在敏感的发育时期，短暂的社会隔离期和高脂肪饮食可能会导致成年后的记忆缺陷。另一方面，隔离和高脂肪饮食之间的相互作用导致了不同的大脑编程，阻止了这些因素单独应用时观察到的一些影响。(C)2016 ISDN。由爱思唯尔有限公司出版。保留所有权利。
Environmental factors, like early exposure to stressors or high caloric diets, can alter the early programming of central nervous system, leading to long-term effects on cognitive function, increased vulnerability to cognitive decline and development of psychopathologies later in life. The interaction between these factors and their combined effects on brain structure and function are still not completely understood. In this study, we evaluated long-term effects of social isolation in the prepubertal period, with or without chronic high fat diet access, on memory and on neurochemical markers in the prefrontal cortex of rats. We observed that early social isolation led to impairment in short-term and working memory in adulthood, and to reductions of Na+,K+-ATPase activity and the immunocontent of phospho-AKT, in prefrontal cortex. Chronic exposure to a high fat diet impaired short-term memory (object recognition), and decreased BDNF levels in that same brain area. Remarkably, the association of social isolation with chronic high fat diet rescued the memory impairment on the object recognition test, as well as the changes in BDNF levels, Na+,K+-ATPase activity, MAPK, AKT and phospho-AKT to levels similar to the control-chow group. In summary, these findings showed that a brief social isolation period and access to a high fat diet during a sensitive developmental period might cause memory deficits in adulthood. On the other hand, the interplay between isolation and high fat diet access caused a different brain programming, preventing some of the effects observed when these factors are separately applied. (C) 2016 ISDN. Published by Elsevier Ltd. All rights reserved.