Micro-/Nano-Structures on Biodegradable Magnesium@PLGA and Their Cytotoxicity, Photothermal, and Anti-Tumor Effects
Micro-/Nano-Structures on Biodegradable Magnesium@PLGA and Their Cytotoxicity, Photothermal, and Anti-Tumor Effects
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可生物降解镁@PLGA的微/纳米结构及其细胞毒性、光热和抗肿瘤作用
DOI：
10.1002/smtd.202000920
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发表时间：
2021
期刊：
影响因子：
12.4
通讯作者：
Kong Tiantian
中科院分区：
文献类型：
--
作者：
Zhou Weixiao;Zhang Yinling;Meng Si;Xing Chenyang;Ma Mingze;Liu Zhou;Yang Chengbin;Kong Tiantian
用于成像剂和治疗剂的颗粒载体的尺寸和结构控制是设计智能递送系统的恒定主题。这是由运载工具的几何参数和功能之间的因果关系所激发的。在此，在体外和体内，研究了具有不同尺寸和壳厚度的可生物降解镁@聚乳酸-羟基乙酸（Mg@PLGA）颗粒载体的细胞毒性、光热和抗肿瘤作用的控制因素。通过微流控乳化制备的Mg@PLGA微球显示出比通过超声均质化制备的纳米球具有更高的Mg包封率（87%）（50%）。发现Mg@PLGA球的光热和抗肿瘤作用取决于其Mg含量，与尺寸和结构特征无关，如体外细胞试验和体内小鼠模型所示。这些结果也为设计和制造刺激响应性药物递送载体提供了重要的启示。
The size and structural control of particulate carriers for imaging agents and therapeutics are constant themes in designing smart delivery systems. This is motivated by the causal relationship between geometric parameters and functionalities of delivery vehicles. Here, both in vitro and in vivo, the controlling factors for cytotoxicity, photothermal, and anti‐tumor effects of biodegradable magnesium@poly(lactic‐co‐glycolic acid (Mg@PLGA) particulate carriers with different sizes and shell thicknesses are investigated. Mg@PLGA microspheres fabricated by microfluidic emulsification are shown to have higher Mg encapsulation efficiency, 87%, than nanospheres by ultrasonic homogenization, 50%. The photothermal and anti‐tumor effects of Mg@PLGA spheres are found to be dictated by their Mg content, irrelevant to size and structural features, as demonstrated in both in vitro cell assays and in vivo mice models. These results also provide important implications for designing and fabricating stimuli‐responsive drug delivery vehicles.