Historical Occupational Trichloroethylene Air Concentrations Based on Inspection Measurements From Shanghai, China
Historical Occupational Trichloroethylene Air Concentrations Based on Inspection Measurements From Shanghai, China
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DOI：
10.1093/annhyg/meu066
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发表时间：
2015-01-01
影响因子：
--
通讯作者：
Vermeulen, Roel
中科院分区：
文献类型：
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作者：
Friesen, Melissa C.;Locke, Sarah J.;Vermeulen, Roel
三氯乙烯 (TCE) 是一种致癌物质，与肾癌以及可能的其他癌症部位（包括非霍奇金淋巴瘤）有关。自 20 世纪 90 年代初以来，随着中国金属、电子和电信行业的发展，其在中国的使用有所增加。我们检查了在中国上海收集的 TCE 检查测量数据库中的历史职业 TCE 空气浓度模式，以确定职业和行业之间的时间趋势和广泛对比。使用 1968 年至 2000 年（中年 1986 年）在上海工作场所收集的 932 个短期区域 TCE 空气检查测量数据库，我们开发了混合效应模型来评估特定工作、行业和时间的 TCE 空气浓度。TCE 空气浓度模型上海工作场所预测，1968 年至 2000 年间，接触量每年减少 5-10%。在洗衣店和干洗店附近收集的测量结果具有最高的预测几何平均值（1986 年的 GM = 150-190mg m(-3)）。大多数 (53%) 测量值是在金属处理作业中收集的。在仅限于金属处理工作测量的模型中，预测 1986 年各行业的 GM 相差 35 倍，从“其他金属产品/维修”行业的 11mg m(-3) 到“船舶/飞机”行业的 390mg m(-3)。1968 年至 2000 年间，中国上海工作场所空气中的 TCE 浓度似乎随着时间的推移而下降。了解不同时间、职业和行业的 TCE 浓度差异可能会有所不同。协助未来中国的流行病学研究。
Trichloroethylene (TCE) is a carcinogen that has been linked to kidney cancer and possibly other cancer sites including non-Hodgkin lymphoma. Its use in China has increased since the early 1990s with China's growing metal, electronic, and telecommunications industries. We examined historical occupational TCE air concentration patterns in a database of TCE inspection measurements collected in Shanghai, China to identify temporal trends and broad contrasts among occupations and industries.Using a database of 932 short-term, area TCE air inspection measurements collected in Shanghai worksites from 1968 through 2000 (median year 1986), we developed mixed-effects models to evaluate job-, industry-, and time-specific TCE air concentrations.Models of TCE air concentrations from Shanghai work sites predicted that exposures decreased 5-10% per year between 1968 and 2000. Measurements collected near launderers and dry cleaners had the highest predicted geometric means (GM for 1986 = 150-190mg m(-3)). The majority (53%) of the measurements were collected in metal treatment jobs. In a model restricted to measurements in metal treatment jobs, predicted GMs for 1986 varied 35-fold across industries, from 11mg m(-3) in 'other metal products/repair' industries to 390mg m(-3) in 'ships/aircrafts' industries.TCE workplace air concentrations appeared to have dropped over time in Shanghai, China between 1968 and 2000. Understanding differences in TCE concentrations across time, occupations, and industries may assist future epidemiologic studies in China.