Stereocontrolled coupling between aldehydes and conjugated alkenals mediated by TiIII/H2O
Stereocontrolled coupling between aldehydes and conjugated alkenals mediated by TiIII/H2O
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DOI：
10.1021/ol0620390
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发表时间：
2006-11-23
期刊：
影响因子：
5.2
通讯作者：
Oltra, J. Enrique
中科院分区：
文献类型：
--
作者：
Estevez, Rosa E.;Oller-Lopez, Juan L.;Oltra, J. Enrique
在水的存在下，二茂钛（III）配合物促进了立体选择性C-C键形成反应，通过醛和共轭烯醛之间的自由基偶联提供-内酯。该方法适用于分子间反应和环化反应。借助模型钛配位中间体，可以准确地预测产物的相对立体化学性质。该过程可以使用手性二茂钛催化剂进行对映选择性反应。
In the presence of water, titanocene(III) complexes promote a stereoselective C-C bond-forming reaction that provides gamma-lactols by radical coupling between aldehydes and conjugated alkenals. The method is useful for both intermolecular reactions and cyclizations. The relative stereochemistry of the products can be predicted with confidence with the aid of model Ti-coordinated intermediates. The procedure can be carried out enantioselectively using chiral titanocene catalysts.