System design and performance of a unilateral horizontal semicircular canal prosthesis
System design and performance of a unilateral horizontal semicircular canal prosthesis
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DOI：
10.1109/10.979358
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发表时间：
2002-02-01
影响因子：
4.6
通讯作者：
Merfeld, DM
中科院分区：
文献类型：
--
作者：
Gong, WS;Merfeld, DM
我们已经报告了关于原型半规管假体的初步结果，并得出结论，它可以提供旋转线索的神经系统。本文介绍了该假体的系统设计，并报告了该假体系统的性能和有效性，该假体通过植入的电极向一侧支配水平半规管的神经分支输送电脉冲。为了使我们能够对两个方向的角速度进行编码，将基线刺激脉冲频率设置为150 Hz，这略高于正常豚鼠中支配半规管的传入神经的平均放电率（类似于60 Hz）。一个传感器测量角速度来调节（增加或减少）脉搏率。动物最初对基线刺激有反应，并在大约一天内适应基线刺激。在此基线适应后，动物对偏航旋转作出反应，表明运河的功能部分恢复。实验还表明，神经系统适应通过电刺激提供的人工旋转提示。
We have reported preliminary results regarding a prototype semicircular canal prosthesis and concluded that it can provide rotational cues to the nervous system. This paper presents the system design of the prosthesis, and also reports the prosthesis system performance and effectiveness.The prosthesis delivers electrical pulses to the nerve branch innervating the horizontal semicircular canal on one side via implanted electrodes. To allow us to encode both directions of angular velocity, the baseline stimulation pulse frequency was set at 150 Hz, which is somewhat higher than; the average firing rate of afferents innervating the semicircular canals in normal guinea pigs (similar to60 Hz). A sensor measures angular velocity to modulate (increase or decrease) the pulse rate.The prosthetic system was provided to a guinea pig whose horizontal canals were surgically plugged. The animal responded to the baseline stimulation initially and adapted to the baseline stimulation in roughly one day. After this baseline adaptation the animal responded to yaw rotation, showing that the function of the canals was partially restored. The experiments also show that the nervous system adapts to the artificial rotational cue provided via electrical stimulation.