Cancer/testis antigen, Kita-Kyushu lung cancer antigen-1 and ABCD stratification for diagnosing gastric cancers
Cancer/testis antigen, Kita-Kyushu lung cancer antigen-1 and ABCD stratification for diagnosing gastric cancers
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DOI：
10.3748/wjg.v26.i4.424
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发表时间：
2020-01-28
影响因子：
4.3
通讯作者：
Takahashi, Yoshihito
中科院分区：
文献类型：
--
作者：
Shida, Akiko;Fukuyama, Takashi;Takahashi, Yoshihito
背景ABCD分层法[结合血清胃蛋白酶原(PG)水平和抗幽门螺杆菌(H.Pylori)抗体(免疫球蛋白G，Ig G)效价]对胃癌高危个体进行分类是有效的。KITA-九州肺癌抗原-1(KK-LC-1)是一种常见的肿瘤/睾丸抗原，常在肿瘤组织中表达。为评价KK-LC-1和ABCD分层在诊断肿瘤中的作用。检测血清Pg I/Pg II和抗Hp抗体。结果77例受检者中，63例(81.8%)表达KK-LC-1。表达KK-LC-1的患者幽门螺杆菌和PG II抗体滴度显著高于不表达KK-LC-1的患者(P=0.0289和P=0.0041)。C组[PG法(+)/Hp感染(+)]KK-LC-1高达93.9%。结论KK-LC-1在胃癌组织中的表达与幽门螺杆菌感染及萎缩状态有关，因此，KK-LC-1可作为诊断胃癌的有用指标。
BACKGROUNDThe ABCD stratification [(combination of serum pepsinogen (PG) levels and titers of antibody (immunoglobulin G, IgG) against Helicobacter pylori (H. pylori)] is effective for the classification of individuals at risk of developing gastric cancer (GC). The Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is a Cancer/Testis antigen frequently expressed in GC.AIMTo evaluate the effectiveness of KK-LC-1 and ABCD stratification in the diagnosis of GC.METHODSWe analyzed the gene expression of KK-LC-1 in surgical specimens obtained from GC tumors. The levels of serum PG I/PG II and IgG against H. pylori were measured. According to their serological status, the patients were classified into the four groups of the ABCD stratification.RESULTSOf the 77 examined patients, 63 (81.8%) expressed KK-LC-1. The IgG titers of H. pylori and PG II were significantly higher in patients expressing KK-LC-1 than those measured in patients not expressing KK-LC-1 (P = 0.0289 and P = 0.0041, respectively). The expression of KK-LC-1 in group C [PG method (+)/H. pylori infection (+)] was as high as 93.9% high. KK-LC-1 was also detected in group A [-/-].CONCLUSIONThe KK-LC-1 expression in GC was associated with H. pylori infection and atrophic status, so that, KK-LC-1 may be a useful marker for the diagnosis of GC.