In-vitro activity of azithromycin and CP-63,956 against Treponema pallidum.
In-vitro activity of azithromycin and CP-63,956 against Treponema pallidum.
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阿奇霉素和 CP-63,956 对抗梅毒螺旋体的体外活性。
DOI：
10.1093/jac/25.suppl_a.11
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Parrish,EA
中科院分区：
文献类型：
--
作者：
Stamm,LV;Parrish,EA
研究了大环内酯类抗生素阿奇霉素及其差向异构体CP-63，956抑制两种致病性梅毒螺旋体蛋白质合成的能力。使用体外放射性标记程序，采用从感染的兔睾丸中新鲜提取的密螺旋体，我们的研究结果表明，这两种抗生素在抑制T. pallidumNichols菌株蛋白质合成的能力方面与红霉素相当。一株红霉素耐药的T.命名为Streetstrain 14的pallidum在测试的最高抗生素浓度下仅表现出蛋白质合成的部分抑制。
The ability of the macrolide antibiotic azithromycin and its epimer CP-63,956 to inhibit protein synthesis in two pathogenic strains ofTreponema pallidumwas investigated. Using an in-vitro radiolabelling procedure employing treponemes freshly extracted from infected rabbit testes, our results indicate that both antibiotics were comparable with erythromycin in their ability to inhibit protein synthesis inT. pallidumNichols strain. An erythromycin-resistant clinical isolate ofT. pallidum, designated Street strain 14, exhibited only partial inhibition of protein synthesis at the highest antibiotic concentration tested.