The role of HOX genes in the development and function of the female reproductive tract
The role of HOX genes in the development and function of the female reproductive tract
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DOI：
10.1055/s-2000-13478
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发表时间：
2000-01-01
影响因子：
2.7
通讯作者：
Taylor, HS
中科院分区：
文献类型：
--
作者：
Taylor, HS
HOX 基因是编码转录因子的调控基因家族，在胚胎发育过程中至关重要。这些基因在物种之间高度保守，因此所有后生动物都拥有共同的胚胎模式遗传系统。该系统在生殖道中保守，其中 HOX 基因参与苗勒管系统的发育。生殖道的不同寻常之处在于 HOX 基因在成人中持续表达。 HOX 基因对于适当的生殖道发育和成人功能都至关重要。本文综述了HOX基因在生殖道发育中的作用以及HOX基因突变对小鼠和人类生殖道发育的影响。然后回顾了 HOX 基因在成人生殖道功能中的作用和调节，特别证明 HOX 基因对人类子宫内膜发育和容受性很重要。
HOX genes are a family of regulatory genes that encode transcription factors and are essential during embryonic development. These genes are highly conserved between species such that all metazoans possess a common genetic system for embryonic patterning. This system is conserved in the reproductive tract, where HOX genes are involved in the development of the mullerian system. The reproductive tract is unusual in that HOX genes continue to be expressed in the adult. HOX genes are essential both for appropriate reproductive tract development and for adult function. This article reviews the role of HOX genes in the development of the reproductive tract and the effect of HOX gene mutations on the development of the reproductive tract in both mice and humans. It then reviews the role and regulation of HOX genes in the adult function of the reproductive tract, specifically evidence that HOX genes are important for human endometrial development and receptivity.