Rare Earth Nanoprobes for Functional Biomolecular Imaging and Theranostics.
Rare Earth Nanoprobes for Functional Biomolecular Imaging and Theranostics.
复制标题
用于功能生物分子成像和治疗诊断的稀土纳米探针。
DOI：
10.1039/c4tb00094c
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发表时间：
2014-05-28
期刊：
影响因子：
--
通讯作者：
Moghe PV
中科院分区：
文献类型：
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作者：
Naczynski DJ;Tan MC;Riman RE;Moghe PV
造影剂的设计，以可视化的分子机制，癌症的发病机制和进展加深了我们对疾病的复杂性的理解，并加快了针对特定的生化途径的增强药物策略的发展。为了使下一代探针和成像系统可行，它们必须表现出增强的灵敏度和对形态学和对比特征的稳健定量，同时提供解析疾病特异性分子特征的能力，这对于重建更全面的病理生物学特征至关重要。这篇专题文章概述了新兴生物医学光学探针的设计和进展，并评估了稀土纳米探针的前景，特别是用于分子成像和治疗诊断学。结合纳米级探针配置的新突破，改进的掺杂剂组合物和多模态红外光学成像，稀土纳米探针可用于解决各种生物医学挑战，包括深层组织成像，实时药物递送跟踪和多光谱分子分析。
Contrast agents designed to visualize the molecular mechanisms underlying cancer pathogenesis and progression have deepened our understanding of disease complexity and accelerated the development of enhanced drug strategies targeted to specific biochemical pathways. For the next generation probes and imaging systems to be viable, they must exhibit enhanced sensitivity and robust quantitation of morphologic and contrast features, while offering the ability to resolve the disease-specific molecular signatures that may be critical to reconstitute a more comprehensive portrait of pathobiology. This feature article provides an overview on the design and advancements of emerging biomedical optical probes in general and evaluates the promise of rare earth nanoprobes, in particular, for molecular imaging and theranostics. Combined with new breakthroughs in nanoscale probe configurations, and improved dopant compositions, and multimodal infrared optical imaging, rare-earth nanoprobes can be used to address a wide variety of biomedical challenges, including deep tissue imaging, real-time drug delivery tracking and multispectral molecular profiling.