Pd(ii)-Catalyzed decarboxylative meta-C-H difluoromethylation
Pd(ii)-Catalyzed decarboxylative meta-C-H difluoromethylation
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Pd(ii) 催化脱羧间位 C-H 二氟甲基化
DOI：
10.1039/c9cc00984a
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发表时间：
2019
影响因子：
4.9
通讯作者：
Wan Wen
中科院分区：
文献类型：
--
作者：
Zhao Huaxin;Ma Guobin;Xie Xiaojuan;Wang Yong;Hao Jian;Wan Wen
以二氟乙酸为原料，研究了钯催化芳烃脱羧间位选择性C-H二氟甲基化反应。初步的机制研究表明，一个合理的迁移插入参与此间-C-H官能化。
A palladium(II)-catalyzed decarboxylative meta-selective C–H difluoromethylation of arenes has been developed from easily accessible difluoroacetic acids. Initial mechanistic studies disclosed that a reasonable migratory insertion is involved in this meta-C–H functionalization.