Semantics in active surveillance for men with localized prostate cancer - results of a modified Delphi consensus procedure
Semantics in active surveillance for men with localized prostate cancer - results of a modified Delphi consensus procedure
复制标题
DOI：
10.1038/nrurol.2017.26
复制
发表时间：
2017-05-01
影响因子：
15.3
通讯作者：
Bangma, Chris H.
中科院分区：
文献类型：
--
作者：
Bruinsma, Sophie M.;Roobol, Monique J.;Bangma, Chris H.
积极监测（AS）被广泛描述为低风险前列腺癌男性的一种管理选择，但在文献和指南中存在语义异质性。为了解决这个问题，一个小组的前列腺癌专家在该领域的AS参加了一个共识形成项目，使用修改后的德尔菲方法，以达成国际共识的定义有关的术语，这种管理选项。每个小组成员完成了一个迭代的三轮在线问卷，旨在解决61个单独的项目。如果超过70%的专家同意定义，则认为达成了协商一致意见。为了促进所有参与的专家达成共识并解决潜在的模糊之处，在第二轮和第三轮德尔菲调查之间举行了一次面对面的协商一致会议。便利抽样被用来构建专家小组。共有来自澳大利亚、法国、芬兰、意大利、荷兰、日本、英国、加拿大和美国的12名专家参加。在德尔菲过程结束时，对100%（n = 61）的术语达成了正式共识，然后制定了术语表。国际专家已就局限性前列腺癌患者AS的相关术语和后续定义达成一致。这一标准术语可以支持多学科交流，减少临床实践中的差异程度，优化临床决策。
Active surveillance (AS) is broadly described as a management option for men with low-risk prostate cancer, but semantic heterogeneity exists in both the literature and in guidelines. To address this issue, a panel of leading prostate cancer specialists in the field of AS participated in a consensus-forming project using a modified Delphi method to reach international consensus on definitions of terms related to this management option. An iterative three-round sequence of online questionnaires designed to address 61 individual items was completed by each panel member. Consensus was considered to be reached if >= 70% of the experts agreed on a definition. To facilitate a common understanding among all experts involved and resolve potential ambiguities, a face-to-face consensus meeting was held between Delphi survey rounds two and three. Convenience sampling was used to construct the panel of experts. In total, 12 experts from Australia, France, Finland, Italy, the Netherlands, Japan, the UK, Canada and the USA participated. By the end of the Delphi process, formal consensus was achieved for 100% (n = 61) of the terms and a glossary was then developed. Agreement between international experts has been reached on relevant terms and subsequent definitions regarding AS for patients with localized prostate cancer. This standard terminology could support multidisciplinary communication, reduce the extent of variations in clinical practice and optimize clinical decision making.