The efficacy of commercially available veterinary diets recommended for dogs with atopic dermatitis
The efficacy of commercially available veterinary diets recommended for dogs with atopic dermatitis
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DOI：
10.1111/j.1365-3164.2008.00688.x
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发表时间：
2008-10-01
影响因子：
1.4
通讯作者：
Mueller, Ralf S.
中科院分区：
文献类型：
--
作者：
Glos, Katharina;Linek, Monika;Mueller, Ralf S.
传统的治疗方法是口服抗过敏药物、过敏原特异性免疫治疗和局部治疗。本项多中心、双盲、随机研究纳入了50只患有特应性皮炎的犬，以比较对三种市售特应性皮炎犬用兽用食品（饲料A-C）或广泛销售的超市食品（饲料D）之一喂食8周的临床反应。特应性皮炎的诊断采用Willemse标准，并通过排除鉴别诊断。将14只犬分配至饲料A，将12只犬分配至饲料B、C或D。在入组研究前和研究期间，使用每月一次的氟虫腈滴剂控制跳蚤和蜱虫至少4周。每月进行评价。这些包括使用已建立的评分系统（犬特应性皮炎程度和严重程度指数，CADESI-03）进行的病变评分和使用视觉模拟量表进行的主人瘙痒水平评价。新饮食8周后，饮食B组的CADESI和瘙痒评分显著改善（Wilcoxon检验，P = 0.043和配对t检验，P = 0.012），饮食A组的瘙痒评分显著改善（配对t检验，P = 0.019），饮食D组的CADESI评分显著改善（Wilcoxon检验，P = 0.037）。在饮食C中未检测到显著变化。根据本研究的结果，除了常规治疗外，改变饮食可能是一种有效的治疗措施。
The classical treatments for dogs with atopic dermatitis have traditionally been oral antipruritic drugs, allergen-specific immunotherapy and topical therapy. Fifty dogs with atopic dermatitis were included in this multicentred, double-blinded, randomized study to compare clinical response to an 8-week period of feeding one of three commercial veterinary foods marketed for dogs with atopic dermatitis (diets A-C) or a widely distributed supermarket food (diet D). Atopic dermatitis was diagnosed using Willemse's criteria and through the exclusion of differential diagnoses. Fourteen dogs were assigned to diet A and 12 dogs each to diet B, C or D. Flea and tick control using a monthly fipronil spot-on product was administered for a minimum of 4 weeks prior to inclusion in the study and during the study period. Evaluations were made monthly. These included lesion scores, using an established scoring system (canine atopic dermatitis extent and severity index, CADESI-03) and owner evaluation of pruritus level using a visual analogue scale. After 8 weeks on the new diets, there was a significant improvement in CADESI and pruritus scores with diet B (Wilcoxon test, P = 0.043 and paired t-test, P = 0.012, respectively), in pruritus scores with diet A (paired t-test, P = 0.019) and in CADESI scores with diet D (Wilcoxon test, P = 0.037). No significant changes were detected with diet C. Based on the results of this study, in addition to the conventional therapies, changing the diet of dogs with atopic dermatitis may be a useful adjunctive therapeutic measure.