Pan-cancer analysis of TASL: a novel immune infiltration-related biomarker for tumor prognosis and immunotherapy response prediction.
Pan-cancer analysis of TASL: a novel immune infiltration-related biomarker for tumor prognosis and immunotherapy response prediction.
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DOI：
10.1186/s12885-023-11015-w
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发表时间：
2023-06-09
期刊：
影响因子：
3.8
通讯作者：
He, Miao
中科院分区：
文献类型：
--
作者：
Li, Huanyu;Sun, Xiaoyu;Zhao, Yanyun;Zhang, Changzhu;Jiang, Kai;Ren, Jie;Xing, Lijuan;He, Miao
迫切需要基于预测因子的新的免疫策略。Toll样受体衔接子与溶酶体上的SLC 15 A4相互作用（TASL）最近被证实在先天免疫应答中发挥重要作用。然而，TASL是否参与肿瘤发展和免疫治疗反应预测尚未报道。 TCGA和GTEx用于产生33种癌症类型中TASL的转录、遗传和表观遗传水平。CIBERSORT用于探索不同癌症类型中TASL表达与多种免疫相关特征和肿瘤浸润免疫细胞含量之间的相关性。在7个数据集中分析了TASL预测肿瘤免疫治疗应答的能力。最后，我们检测了TASL在人脑胶质瘤细胞系和组织样本中的表达，并分析了其与临床病理参数的相关性。TASL在转录、遗传和表观遗传水平上具有广泛的异质性。TASL高表达是免疫“冷”肿瘤低级别胶质瘤（LGG）的独立预后不良因素，但对于“热”肿瘤肺腺癌（LUAD）和皮肤皮肤黑色素瘤（SKCM）是相反因素。TASL可能通过介导肿瘤浸润淋巴细胞和肿瘤相关巨噬细胞影响肿瘤免疫浸润。它可能通过调节LGG中的免疫抑制微环境和LUAD和SKCM中的免疫刺激微环境而不同地影响三种癌症的预后。高TASL表达是癌症（如SKCM）对免疫治疗的阳性反应的潜在生物标志物，并且也被实验证实与神经胶质瘤的不良临床病理学特征正相关。TASL表达是LGG、LUAD和SKCM的独立预后因素。高TASL表达是某些癌症类型（如SKCM）对免疫疗法的阳性反应的潜在生物标志物。因此，迫切需要对TASL表达和肿瘤免疫治疗进行进一步的基础研究。在线版本包含补充材料，可通过10.1186/s12885-023-11015-w获得。
New immunotherapeutic strategies based on predictors are urgently needed. Toll-like receptor adaptor interacting with SLC15A4 on the lysosome (TASL) was recently confirmed to fulfill an important role in the innate immune response. However, whether TASL is involved in tumor development and immunotherapy response prediction has not been reported. TCGA and GTEx were used to yield transcriptional, genetic, and epigenetic levels of TASL in 33 cancer types. CIBERSORT was used to explore the correlation between TASL expression and multiple immune-related signatures and tumor-infiltrating immune cell content in different cancer types. The ability of TASL to predict tumor immunotherapy response was analyzed in seven datasets. Finally, we tested TASL expression in human glioma cell lines and tissue samples and analyzed its correlation with clinicopathological parameters. TASL is widely heterogeneous at the transcriptional, genetic, and epigenetic levels. High TASL expression is an independent poor prognostic factor for immune “cold” tumor Low-Grade Glioma (LGG) but an opposite factor for “hot” tumors Lung Adenocarcinoma (LUAD) and Skin Cutaneous Melanoma (SKCM). TASL may affect tumor immune infiltration by mediating tumor-infiltrating lymphocytes and tumor-associated macrophages. It may differentially affect the prognosis of the three cancers by regulating the immunosuppressive microenvironment in LGG and the immunostimulatory microenvironment in LUAD and SKCM. High TASL expression is a potential biomarker for the positive response to immunotherapy in cancers such as SKCM and was also experimentally confirmed to be positively associated with adverse clinicopathological features of gliomas. TASL expression is an independent prognostic factor for LGG, LUAD, and SKCM. High TASL expression is a potential biomarker for the positive response to immunotherapy in certain cancer types such as SKCM. Further basic studies focusing on TASL expression and tumor immunotherapy are urgently needed. The online version contains supplementary material available at 10.1186/s12885-023-11015-w.
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影响因子：
29
作者：
Cascone T;McKenzie JA;Mbofung RM;Punt S;Wang Z;Xu C;Williams LJ;Wang Z;Bristow CA;Carugo A;Peoples MD;Li L;Karpinets T;Huang L;Malu S;Creasy C;Leahey SE;Chen J;Chen Y;Pelicano H;Bernatchez C;Gopal YNV;Heffernan TP;Hu J;Wang J;Amaria RN;Garraway LA;Huang P;Yang P;Wistuba II;Woodman SE;Roszik J;Davis RE;Davies MA;Heymach JV;Hwu P;Peng W
通讯作者：
Peng W
影响因子：
4.6
作者：
Bonneville R;Krook MA;Kautto EA;Miya J;Wing MR;Chen HZ;Reeser JW;Yu L;Roychowdhury S
通讯作者：
Roychowdhury S
影响因子：
11.2
作者：
Huang, B;Zhao, J;Xiong, HB
通讯作者：
Xiong, HB
影响因子：
11.2
作者：
Gallotta, Marilena;Assi, Hikmat;Guiducci, Cristiana
通讯作者：
Guiducci, Cristiana
影响因子：
15.9
作者：
Dubbink, Hendrikus J.;Atmodimedjo, Peggy N.;van den Bent, Martin J.
通讯作者：
van den Bent, Martin J.