Cutaneous tissue angiotensin-converting enzyme may participate in pathologic scar formation in human skin
Cutaneous tissue angiotensin-converting enzyme may participate in pathologic scar formation in human skin
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DOI：
10.1016/j.jaad.2005.09.027
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发表时间：
2006-02-01
影响因子：
13.8
通讯作者：
Kishimoto, S
中科院分区：
文献类型：
--
作者：
Morihara, K;Takai, S;Kishimoto, S
背景：许多研究表明，血管紧张素转换酶(ACE)的上调参与了不利的纤维重塑。虽然这在心血管领域已经成为公认的事实，但血管紧张素转换酶与皮肤纤维重塑，如瘢痕疙瘩或增生性瘢痕的关系仍不清楚。目的：我们试图研究血管紧张素转换酶在正常皮肤、创伤皮肤和病理性瘢痕中的作用。用高压液相色谱法测定皮肤组织血管紧张素转换酶(ACE)活性。结果：病理性瘢痕组织中ACE活性明显高于正常皮肤和创面组织。免疫组织化学研究表明，肌成纤维细胞被抗ACE抗体染色。限制：这项研究规模较小。结论：这些结果表明，上调的ACE可能与心血管系统一样参与皮肤病理性瘢痕的形成。
Background: Many studies have shown that up-regulation of angiotensin-converting enzyme (ACE) participates in adverse fibrous remodeling. Although this has become an accepted fact in the cardiovascular field, the relationship between ACE and cutaneous fibrous remodeling, such as keloid or hypertrophic scars, remains unknown.Objective: We Sought to investigate ACE in normal skin, wounded skin, and pathologic scars.Methods: Ten samples undergoing a normal wound-healing process, 14 samples of pathologic scar tissue, and 15 samples of normal skin were used in this study. Cutaneous tissue ACE activities were measured with high-pressure liquid chromatography. Localization of ACE was assessed by immunohistochemistry.Results: The ACE activity in pathologic scar tissue was significantly higher than in normal and wounded skin. Immunohistochemical studies demonstrated that myofibroblasts were stained with anti-ACE antibody.Limitations: The study is small.Conclusions: These results suggest that up-regulated ACE may participate in cutaneous pathologic scar formation the same as the cardiovascular system.