Structural white matter alterations in male adults with high functioning autism spectrum disorder and concurrent depressive symptoms; a diffusion tensor imaging study.
Structural white matter alterations in male adults with high functioning autism spectrum disorder and concurrent depressive symptoms; a diffusion tensor imaging study.
复制标题
DOI：
10.1016/j.jad.2019.08.010
复制
发表时间：
2019-12
影响因子：
6.6
通讯作者：
B. Mohajer;M. Masoudi;Agaah Ashrafi;Esmaeil Mohammadi;Amir Sasan Bayani Ershadi;M. Aarabi;K. Uban
中科院分区：
文献类型：
--
作者：
B. Mohajer;M. Masoudi;Agaah Ashrafi;Esmaeil Mohammadi;Amir Sasan Bayani Ershadi;M. Aarabi;K. Uban
研究背景自闭症谱系障碍（Autism spectrum disorder，ASD）是一种常见的发育障碍，常伴有心境障碍，尤其是抑郁症.在这里，我们探讨了脑白色物质微结构完整性之间的潜在关联，通过扩散张量成像（DTI）评估，和抑郁症状，在男性成年人与高功能ASD.MethodTo评估我们的主要目的，自闭症脑成像数据交换II数据集被用来获取脑扩散成像从26名成年男性患者与ASD，年龄从18岁到62岁，和26名年龄和性别匹配的典型发育对照受试者。通过贝克抑郁指数（BDI）评估参与者的抑郁症状表现。在“ExploreDTI”工具箱中对DWI图像进行预处理和DTI缩放器分析。使用了校正的线性回归模型。标准化BDI评分及其与诊断的相互作用，作为预测因子，和分数各向异性（FA）和平均扩散率（MD）的区域感兴趣的措施之间的关联根据Mori atlas assessed.ResultsSignificant较低的微结构完整性的白色物质被发现与较高的BDI分数在ASD组，主要是在该地区的前肢内囊（ALIC）和冠辐射。此外，在FA的左ALIC.DiscussionConsidering类似的区域脑白色物质参与抑郁症的成像研究中的典型发达的人口，我们建议，这些改变的白色物质束在抑郁症状的成人ASD受试者可能是，至少，类似于抑郁症在典型发达的人口。
BackgroundAutism spectrum disorder (ASD), a prevalent developmental condition, is associated with comorbid mood disorders, most importantly depression. Here, we explored the underlying association between brain white matter microstructural integrity, assessed by diffusion tensor imaging (DTI), and depressive symptoms, in male adults with high-functioning ASD.MethodTo assess our main purpose, Autism Brain Imaging Data Exchange II dataset was used to acquire brain diffusion imaging from 26 adult male patients with ASD ranging from 18 to 62 years of age, and 26 age and gender-matched typically developed control subjects. Participants were evaluated for depressive symptoms manifestation by the Beck Depression Index (BDI). DWI images were preprocessed and analyzed for DTI scalers in the “ExploreDTI” toolbox. Adjusted linear regression models were used. Association between normalized BDI score and its interaction with diagnosis, as predictors, and measures of fractional anisotropy (FA) and mean diffusivity (MD) of regions of interest according to Mori atlas was assessed.ResultSignificant lower microstructural integrity of white matter was found in association with higher BDI scores in ASD group, mainly in regions of anterior limb of internal capsule (ALIC) and corona radiata. Also, a statistically significant positive interaction between BDI and ASD was seen in FA of left ALIC.DiscussionConsidering similar regional brain white matter involvement with the imaging studies of depression in the typically developed population, we propose that these alterations of white matter tracts in depressive symptoms of adult ASD subjects might be, at least, similar to depression in typically developed population.