Chemical modification of nodulisporic acid A: Preliminary structure-activity relationships
Chemical modification of nodulisporic acid A: Preliminary structure-activity relationships
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DOI：
10.1016/s0960-894x(00)00469-8
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发表时间：
2000-10-16
影响因子：
2.7
通讯作者：
Fisher, MH
中科院分区：
文献类型：
--
作者：
Meinke, PT;Ayer, MB;Fisher, MH
药物化学的努力，开始确定关键成分的nodulisporic酸A（1）药效团是不可或缺的，其强大的杀虫活性。新的半合成衍生物划定1到“许可”和“nonpermissive”的地区，并导致发现新的nodulisporamides具有显着提高跳蚤的疗效。(C)2000爱思唯尔科技有限公司版权所有。
Medicinal chemistry efforts were initiated to identify the key constituents of the nodulisporic acid A (1) pharmacophore that are integral to its potent insecticidal activity. New semisynthetic derivatives delineated 1 into 'permissive' and 'nonpermissive' regions and led to the discovery of new nodulisporamides with significantly improved flea efficacy. (C) 2000 Elsevier Science Ltd. All rights reserved.