Carbon Dots as a Potential Therapeutic Agent for the Treatment of Cancer-Related Anemia
Carbon Dots as a Potential Therapeutic Agent for the Treatment of Cancer-Related Anemia
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碳点作为治疗癌症相关贫血的潜在治疗剂
DOI：
10.1002/adma.202200905
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发表时间：
2022-04-09
影响因子：
29.4
通讯作者：
Zhang，Shijie
中科院分区：
文献类型：
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作者：
Xu，Yuanlin;Wang，Boyang;Zhang，Shijie
由于促红细胞生成素（EPO）对癌症患者生存的不利影响，有必要开发可用于有效管理和治疗癌症相关贫血的新药物。在这项研究中，新的独特的碳量子点，J-CD，来自枣设计，合成和表征。基于所获得的结果，该材料包含sp2和sp3碳原子以及氧/氮基基团，并且其通过在体外和体内刺激红系祖细胞的自我更新来特异性地促进红系细胞的增殖。此外，与EPO不同，J-CD对肿瘤增殖和转移没有明显的影响。转录组分析表明，J-CD上调参与缺氧反应的分子，并且它们还显著增加STAT 5的磷酸化水平，STAT 5是红系祖细胞增殖的主要信号转导子。总的来说，这项研究表明，J-CD有效地促进红细胞生成，而不影响肿瘤增殖和转移;因此，它们可能是治疗癌症相关贫血的有希望的药物。
Due to the adverse effects of erythropoietin (EPO) on cancer patient survival, it is necessary to develop new agents that can be used to efficiently manage and treat cancer‐related anemia. In this study, novel distinctive carbon dots, J‐CDs, derived from jujube are designed, synthesized, and characterized. Based on the obtained results, this material comprises sp2and sp3carbon atoms, as well as oxygen/nitrogen‐based groups, and it specifically promotes the proliferation of erythroid cells by stimulating the self‐renewal of erythroid progenitor cells in vitro and in vivo. Moreover, J‐CDs have no discernible effects on tumor proliferation and metastasis, unlike EPO. Transcriptome profiling suggests that J‐CDs upregulate the molecules involved in hypoxia response, and they also significantly increase the phosphorylation levels of STAT5, the major transducer of signals for erythroid progenitor cell proliferation. Overall, this study demonstrates that J‐CDs effectively promote erythrocyte production without affecting tumor proliferation and metastasis; thus, they may be promising agents for the treatment of cancer‐related anemia.