Presenile cataract formation and decreased activity of galactosemic enzymes.
Presenile cataract formation and decreased activity of galactosemic enzymes.
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早老性白内障形成和半乳糖酶活性降低。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
J. Prchal
中科院分区：
文献类型：
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作者：
H. W. Skalka;J. Prchal
对147例晚期白内障患者进行了红细胞半乳糖-1-磷酸转移酶和半乳糖-1-磷酸尿苷转移酶测定。在50岁或以下的老年前期“特发性”双眼患者中，47.4%的患者上述酶中的一种酶显著降低(>2个SD)，在50岁或以下的其他患者中，7.1%的患者中，在51岁或以上的患者中，3.8%的患者中有一种酶的活性显著降低。老年前期特发性白内障组与其他组之间差异有高度统计学意义(P<.001)。半乳糖激酶或半乳糖-1-磷酸尿苷转移酶活性降低的患者(推测为杂合子)约占总人口的1%，似乎更容易形成特发性早老性白内障，并可能更容易在各种晶状体侮辱后形成继发性白内障。限制牛奶和奶制品的饮食可以预防或延缓这些人的白内障形成。
One hundred forty-seven patients, 144 with advanced cataract formation, had determinations of erythrocyte galactokinase and galactose-1-phosphate uridyl transferase performed. Significant reduction (more than 2 SDs) of one of these enzymes was found in 47.4% of patients 50 years old or less with presenile "idiopathic" bilateral cataracts, 7.1% of other patients with cataracts aged 50 years or less, and 3.8% of patients with cataracts aged 51 years or more. The differences between the group with presenile idiopathic cataracts and the other groups were statistically highly significant (P less than .001). Patients with reduced activity of galactokinase or galactose-1-phosphate uridyl transferase (presumed heterozygotes) compose about 1% of the general population, appear to be more susceptible to idiopathic presenile cataract formation, and may be more prone to secondary cataract formation after a variety of lenticular insults. Dietary restriction of milk and milk products may prevent or delay cataract formation in these individuals.