Immunochemical characterization of the plasmin-antiplasmin system. Basis for the specific detection of the plasmin-antiplasmin complex by latex agglutination assays.
Immunochemical characterization of the plasmin-antiplasmin system. Basis for the specific detection of the plasmin-antiplasmin complex by latex agglutination assays.
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纤溶酶-抗纤溶酶系统的免疫化学表征。
DOI：
10.1055/s-0038-1651913
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
D. Collen
中科院分区：
文献类型：
--
作者：
E. Plow;F. De Cock;D. Collen
血小板通过粘附于暴露的内皮下血管壁结构，随后释放触发血小板聚集的物质，以及促进凝血因子相互作用的血小板表面性质的释放相关变化，导致形成稳定初始止血塞所需的纤维蛋白，在血液对血管损伤的反应中发挥关键作用。体外研究中有大量证据表明，血小板也可能影响纤溶纤溶酶原-纤溶酶系统，纤溶酶原-纤溶酶系统被认为是重要的止血调节机制之一，可防止止血塞不当延伸，从而导致血栓性血管闭塞。本文综述了血小板及其相关因子对纤溶酶原-纤溶酶系统的激活和功能的影响。实验结果表明，血小板可能有助于纤维蛋白凝块的稳定，通过从其储存细胞器中释放抑制纤溶酶原激活和纤溶酶作用的物质。血小板介导的纤溶酶抑制纤溶的生理和病理生理意义，以及其他潜在的重要的血浆和细胞纤溶酶，仍然在很大程度上受到推测，似乎是未来研究的一个重要领域。
Blood platelets play a crucial role in the response of blood to vascular injury through adherence to exposed subendothelial vessel wall structures, the subsequent release of substances which trigger platelet aggregation, and release-associated changes in platelet surface properties which facilitate the interaction of coagulation factors, leading to the formation of fibrin necessary for stabilization of the initial hemostatic plug. There is substantial evidence from in vitro studies to suggest that platelets may also affect the fibrinolytic plasminogen-plasmin system thought to be one of the important hemostatic regulatory mechanisms preventing inappropriate extension of the hemostatic plug which may lead to thrombotic vessel occlusion. In this paper, the published experimental evidence concerning the effects of platelets and platelet-associated factors on the activation and function of the plasminogen-plasmin system is reviewed. The experimental findings indicate that platelets may contribute to fibrin clot stabilization through the release of substances from their storage organelles which inhibit both plasminogen activation and the action of plasmin. The physiologic and pathophysiologic significance of platelet-mediated inhibition of fibrinolysis by plasmin, as well as other potentially important plasma and cellular fibrinolytic enzymes, is still largely subject to speculation and appears to be an important area for future investigation.