Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus.
Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus.
复制标题
来自内侧内嗅皮层的端脑输出被直接复制到海马体。
DOI：
10.7554/elife.73162
复制
发表时间：
2022-02-21
期刊：
影响因子：
7.7
通讯作者：
Sürmeli G
中科院分区：
文献类型：
--
作者：
Tsoi SY;Öncül M;Svahn E;Robertson M;Bogdanowicz Z;McClure C;Sürmeli G
新大脑皮层和海马体的互补作用使依赖经验的记忆得以编码和长期存储。记忆存储的标准模型假设感觉信号从内嗅皮层(EC)的浅层到达海马体。另一方面，EC的深层将海马神经元的输出传递到端脑结构，包括新皮质的许多部分。在这里，我们显示了内侧EC 5a层的细胞将它们的端脑输出的副本发送回海马区的CA1区。结合特定细胞类型的解剖示踪、基于高通量RNA测序的投影图谱和光遗传学辅助的电路图谱，我们发现在小鼠大脑中，这些投影具有独特的地形图，并以海马体锥体细胞和中间神经元为靶点。我们的结果表明，深内侧EC神经元的投射在解剖学上被配置为同时影响海马和新皮质，从而导致关于深EC功能作用的新假说。
Complementary actions of the neocortex and the hippocampus enable encoding and long-term storage of experience dependent memories. Standard models for memory storage assume that sensory signals reach the hippocampus from superficial layers of the entorhinal cortex (EC). Deep layers of the EC on the other hand relay hippocampal outputs to the telencephalic structures including many parts of the neocortex. Here, we show that cells in layer 5a of the medial EC send a copy of their telencephalic outputs back to the CA1 region of the hippocampus. Combining cell-type-specific anatomical tracing with high-throughput RNA-sequencing based projection mapping and optogenetics aided circuit mapping, we show that in the mouse brain these projections have a unique topography and target hippocampal pyramidal cells and interneurons. Our results suggest that projections of deep medial EC neurons are anatomically configured to influence the hippocampus and neocortex simultaneously and therefore lead to novel hypotheses on the functional role of the deep EC.