IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains
IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains
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DOI：
10.1016/j.dci.2004.07.003
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发表时间：
2005-01-01
影响因子：
2.9
通讯作者：
Lefranc, G
中科院分区：
文献类型：
--
作者：
Lefranc, MP;Pommié, C;Lefranc, G
IMGT，国际免疫遗传学信息系统（R）（http://imgt.cines.fr）提供了对有关基因组，蛋白质组，遗传学和免疫球蛋白（Ig），T细胞受体（TR）的熟悉注释数据的共同访问，人和其他脊椎动物的免疫系统（RPI）的主要组织相容性复合物（MHC）和相关蛋白。 IMGT-主页的数字概念允许为变量域（V域）和V样域定义一个唯一的编号。在本文中，这种标准化的特征扩展到恒定域（C域）和c样域的领先。第一次，他们对突变，等位基因多态性，二维（2D）表示和三维（3D）结构的标准化描述。因此，IMGT独特的编号对于免疫球蛋白超家族（IGSF）域的比较，结构或进化研究非常有价值。脊椎动物中Ig和TR的V域和C域，以及Ig和Tr以外的任何物种中Ig和TR以外的V样蛋白的V样蛋白。 （c）2004 Elsevier Ltd.保留所有权利。
IMGT, the international ImMunoGeneTics information system(R) (http://imgt.cines.fr) provides a common access to expertly annotated data on the genome, proteome, genetics and structure of immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC), and related proteins of the immune system (RPI) of human and other vertebrates. The NUMEROTATION concept of IMGT-ONTOLOGY has allowed to define a unique numbering for the variable domains (V-DOMAINs) and for the V-LIKE-DOMAINs. In this paper, this standardized characterization is extended to the constant domains (C-DOMAINs), and to the C-LIKE-DOMAINs, leading. for the first time, to their standardized description of mutations, allelic polymorphisins, two-dimensional (2D) representations and tridimensional (3D) structures. The IMGT unique numbering is, therefore, highly valuable for the comparative, structural or evolutionary studies of the immunoglobulin superfamily (IgSF) domains. V-DOMAINs and C-DOMAINs of IG and TR in vertebrates, and V-LIKE-DOMAINs and C-LIKE-DOMAINs of proteins other than IG and TR, in any species. (C) 2004 Elsevier Ltd. All rights reserved.