MRI-guided focused ultrasound surgery in the brain: Tests in a primate model
MRI-guided focused ultrasound surgery in the brain: Tests in a primate model
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DOI：
10.1002/mrm.10453
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发表时间：
2003-06-01
影响因子：
3.3
通讯作者：
Hynynen, K
中科院分区：
文献类型：
--
作者：
McDannold, N;Moss, M;Hynynen, K
在恒河猴的大脑中测试了 MRI 引导的聚焦超声。目标深度达 4.8 厘米。通过 MRI 衍生的温度成像，在所有病例中均观察到局部加热。当超声波束以低功率超声处理为目标时，在焦点处观察到亚阈值加热，在高功率照射期间，在超声波束路径中观察到亚阈值加热。致死温度值和组织学证实的组织损伤仅限于焦点区域（例如，不在超声波束路径中），除非焦点靠近骨骼。在这种情况下，观察到邻近脑组织受损。在组织学检查中观察到局灶性病变，在某些情况下，在超声照射后立即获取的 MR 图像中观察到局灶性病变。这项研究中展示的功能将有益于大脑的临床超声治疗。 (C) 2003 Wiley-Liss, Inc.
MRI-guided focused ultrasound was tested in the brains of rhesus monkeys. Locations up to 4.8 cm deep were targeted. Focal heating was observed in all cases with MRI-derived temperature imaging. Subthreshold heating was observed at the focus when the ultrasound beam was targeted with low power sonications, and in the ultrasound beam path during high-power exposures. Lethal temperature values and histologically confirmed tissue damage were confined to the focal zone (e.g., not in the ultrasound beam path), except when the focus was close to the bone. In that case, damage to the neighboring brain tissue was observed. Focal lesions were observed on histological examination and, in some cases, in MR images acquired immediately after the ultrasound exposures. The capabilities demonstrated in this study will be of benefit for clinical ultrasound therapies in the brain. (C) 2003 Wiley-Liss, Inc.