Domestic control of house dust mite allergen in children's beds
Domestic control of house dust mite allergen in children's beds
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DOI：
10.1067/mai.2000.106213
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发表时间：
2000-06-01
影响因子：
14.2
通讯作者：
Tovey, ER
中科院分区：
文献类型：
--
作者：
Vanlaar, CH;Peat, JK;Tovey, ER
背景：澳大利亚潮湿沿海地区的屋尘螨过敏原水平很高，特别是在床上。因为高过敏原水平的床与更严重的哮喘，减少水平可能是重要的哮喘control.Objective：我们测试了有效性的杀螨治疗的床上用品结合闭塞床垫和枕头套在减少过敏原水平的儿童的床在社区setting.Methods：共14床的儿童被选中的积极干预。在每个家庭中，选择年龄最接近的兄弟姐妹的床作为对照。通过使用标准方案从床上吸尘，并且仅通过使用ELISA测量Der p 1水平。通过使用打开的培养皿收集邻近的沉降粉尘。干预措施包括将床垫和枕头包裹在封闭罩中，并用杀螨添加剂Acaril清洗所有床上用品。7个家庭每隔2个月重复使用两次杀螨洗液。结果：活动床和对照床的基线Der p 1平均浓度分别为27.9 μ g/g和18.1 μ g/g。在干预后4天，Der p 1在活性床和对照床中分别降至32 μ g/g和15.7 μ g/g。在第一个1周周期内的平均差异（活性物减去对照物）为78.5%（P < .0001），在3个洗涤周期内的差异为125.1%（P < .05）。在积极治疗的病床附近，Der p 1的平均沉降速率从基线时的24.4 ng.m（-2）.d（-1）降至干预后的10.0 ng.m（-2）.d（-1结论：在具有天然高屋尘螨过敏原水平的潮湿地区，社区设置，使用封闭盖和严格的清洗程序。
Background: House dust mite allergen levels in humid coastal regions of Australia are high, particularly in beds. Because high allergen levels in beds are associated with more severe asthma, reduction of levels may be important for asthma control.Objective: We tested the effectiveness of an acaricidal treatment of bedding in combination with occlusive mattress and pillow encasings in reducing allergen levels in children's beds in a community setting.Methods: A total of 14 beds of children were selected for the active intervention. In each home the bed of a sibling of nearest age was selected as the control. Dust was vacuumed from beds by using a standard protocol, and Der p 1 levels mere measured by using ELISA. Adjacent settling dust was collected by using opened Petri dishes. The intervention consisted of encasing mattresses and pillows in occlusive covers and washing all bedding with Acaril, an acaricidal additive. The acaricidal wash mas repeated twice in 7 households at 2-month inter vals. Control beds mere not treated.Results: The mean Der p 1 concentration at baseline was 27.9 mu g/g in the active beds and 18.1 mu g/g in the control beds. At 4 days after intervention, Der p 1 decreased to 32 mu g/g and 15.7 mu g/g in active and control beds, respectively. The average difference (active minus control) over the first 1-week cycle was 78.5% (P < .0001), and the difference over 3 washing cycles was 125.1% (P < .05). The mean rate of settling Der p 1 adjacent to the actively treated beds decreased from 24.4 ng.m(-2).d(-1) at baseline to 10.0 ng.m(-2).d(-1) after intervention (P < .01).Conclusion: A substantial reduction in Der p 1 levels in beds and in airborne dust in a humid region with naturally high house dust mite allergen levels can be achieved and sustained in a community setting with use of occlusive covers and a rigorous washing routine.