LESION OF CENTRAL NUCLEUS OF AMYGDALA PROMOTES FAT GAIN WITHOUT PREVENTING EFFECT OF EXERCISE ON ENERGY-BALANCE
LESION OF CENTRAL NUCLEUS OF AMYGDALA PROMOTES FAT GAIN WITHOUT PREVENTING EFFECT OF EXERCISE ON ENERGY-BALANCE
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DOI：
10.1152/ajpregu.1995.269.4.r781
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发表时间：
1995-10-01
影响因子：
2.8
通讯作者：
RICHARD, D
中科院分区：
文献类型：
--
作者：
BOVETTO, S;RICHARD, D
将杏仁中央核（CeA）毁损或完整的雄性Wistar大鼠连续21天保持安静或进行跑台运动。在整个运动训练计划中监测食物摄入量和体重。实验结束后，处死大鼠，并对尸体进行处理，以分析能量、脂肪和蛋白质的含量。运动和CeA病变对能量平衡产生相反的影响;运动延迟了身体能量和脂肪的增加，而CeA病变促进了它们。总能量摄入量低于运动大鼠比久坐的12和24小时后，运动。在运动后12小时的后半部分，损伤大鼠的食物摄入量高于完整动物。运动和CeA病变对能量平衡和摄入以及身体成分没有相互作用。运动组血浆促肾上腺皮质激素和皮质酮水平明显高于安静组，但损伤组与正常组无显著差异。这项研究，以及确认运动对能量平衡的影响，表明CeA病变可能会促进大鼠的能量沉积。总之，本研究结果提供的证据表明，CeA并不代表一个必要的神经解剖结构的运动能量平衡的影响。
Male Wistar rats with intact or lesioned central nucleus of amygdala (CeA) were kept at rest or subjected to a treadmill running program for 21 consecutive days. Food intake and body weight were monitored throughout the exercise training program. At the end of the program, rats were killed and their carcasses processed for analysis of the contents in energy, fat, and protein. Exercise and CeA lesions induced opposite effects on energy balance; exercise delayed gains in body energy and fat, whereas CeA lesions promoted them. Total energy intake was lower in exercised rats than in sedentary ones over the 12 and 24 h that followed exercise. Food intake was higher in lesioned rats than in intact animals over the second half of the 12-h period that followed exercise. There was no interaction effect of exercise and CeA lesions on energy balance and intake and on body composition. Plasma levels of adrenocorticotropin hormone and corticosterone were higher in exercised rats than in sedentary ones, but there was no difference between lesioned and intact rats. This study, as well as confirming the effect of exercise on energy balance, indicates that CeA lesions may promote energy deposition in rats. Above all the present results provide evidence that CeA does not represent a necessary neuroanatomic structure in the effect of exercise on energy balance.