Determinants of troponin release in patients with stable coronary artery disease: insights from CT angiography characteristics of atherosclerotic plaque
Determinants of troponin release in patients with stable coronary artery disease: insights from CT angiography characteristics of atherosclerotic plaque
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DOI：
10.1136/hrt.2010.193201
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发表时间：
2011-05-01
期刊：
影响因子：
5.7
通讯作者：
Katus, Hugo A.
中科院分区：
文献类型：
--
作者：
Korosoglou, Grigorios;Lehrke, Stephanie;Katus, Hugo A.
目的比较高敏肌钙蛋白T（hsTnT）水平与冠状动脉粥样硬化斑块CT血管造影（CTA）特征，探讨稳定型冠心病（CAD）患者血清hsTnT水平的变化及其与冠心病的关系。CTA评价冠状动脉钙化程度、狭窄程度、非钙化斑块体积、冠状动脉狭窄程度。（4）菌斑组成（软的或混合的，描述为“非钙化”与钙化）和（5）在非钙化斑块区域中血管重构的存在。1830/1848个可用冠状动脉节段（99.0%）达到诊断图像质量。在29/124例患者中，hsTnT>= 14 pg/ml（范围14.0-34.4）。hsTnT和钙评分之间存在微弱的相关性（r=0.45，p
Objective To understand the determinants of troponin release in patients with stable coronary artery disease (CAD) by comparing high sensitive troponin T (hsTnT) levels with computed tomography angiography (CTA) characteristics of atherosclerotic plaque.Methods hsTnT was determined in 124 consecutive patients with stable angina, who underwent clinically indicated 256-slice CTA for suspected CAD. CTA was used to assess (1) coronary calcification; (2) stenosis severity; (3) non-calcified plaque volume; (4) plaque composition (soft or mixed, described as 'non-calcified' versus calcified) and (5) the presence of vascular remodeling in areas of non-calcified plaque.Results All CT scans were performed without adverse events, and diagnostic image quality was achieved in 1830/1848 available coronary segments (99.0%). In 29/124 patients, hsTnT was >= 14 pg/ml (range 14.0-34.4). Weak, albeit significant, correlations were found between hsTnT and calcium scoring (r=0.45, p