In vivo definition of parieto-motor connections involved in planning of grasping movements
In vivo definition of parieto-motor connections involved in planning of grasping movements
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DOI：
10.1016/j.neuroimage.2010.02.022
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发表时间：
2010-05-15
期刊：
影响因子：
5.7
通讯作者：
Bozzali, Marco
中科院分区：
文献类型：
--
作者：
Koch, Giacomo;Cercignani, Mara;Bozzali, Marco
我们结合双焦点经颅磁刺激（TMS）和弥散张量成像（DTI）神经束成像来研究人类不同顶叶区域的连接在规划不同伸手抓握动作中的作用。经颅磁刺激实验显示，在左半球初级运动皮层（M1）和靠近尾端顶叶内沟的角回（AG）之间的功能连接，只有在对侧空间的物体进行全手抓握（WHG）运动时，才会在早期准备伸手和抓握运动时被激活。相比之下，另一条连接M1与靠近顶叶前沟的边缘上回（SMG）部分的不同通路，仅对所需抓取的类型（精确抓取）敏感，而对物体在空间中的位置不敏感。三线圈实验显示，连续的θ波爆发刺激使腹侧运动前区（PMv）失活，干扰了其中的一些相互作用。解剖DTI束状图显示，AG和SMG通过不同的上纵束束（SLF）与PMv和M1紧密相连。这些结果表明，分离的顶叶-前运动-运动通路的存在对于准备不同的抓取动作至关重要，并表明这些通路可能处理与物体位置和使用它所需的手形状相关的信息。(C) 2010爱思唯尔公司版权所有。
We combined bifocal transcranial magnetic stimulation (TMS) and diffusion tensor imaging (DTI) tractography to investigate in humans the contribution of connections originating from different parietal areas in planning of different reaching to grasp movements. TMS experiments revealed that in the left hemisphere functional connectivity between the primary motor cortex (M1) and a portion of the angular gyrus (AG) close to the caudal intraparietal sulcus was activated during early preparation of reaching and grasping movements only when the movement was made with a whole hand grasp (WHG) towards objects in contralateral space. In contrast, a different pathway, linking M1 with a part of the supramarginal gyrus (SMG) close to the anterior intraparietal sulcus, was sensitive only to the type of grasp required (precision grasping) but not to the position of the object in space. A triple coil experiment revealed that inactivation of the ventral premotor area (PMv) by continuous theta burst stimulation interfered with some of these interactions. Anatomical DTI tractography revealed that AG and SMG are strongly connected with PMv and with M1 by different bundles of the superior longitudinal fasciculus (SLF).These results demonstrate the existence of segregated parieto-premotor-motor pathways crucial for preparation of different grasping actions and indicate that these may process information relevant to both the position of the object and the hand shape required to use it. (C) 2010 Elsevier Inc. All rights reserved.