Cardiac fibroblast activation during myocardial infarction wound healing
Cardiac fibroblast activation during myocardial infarction wound healing
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DOI：
10.1016/j.matbio.2020.03.010
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发表时间：
2020-09-01
期刊：
影响因子：
6.9
通讯作者：
Lindsey, Merry L.
中科院分区：
文献类型：
--
作者：
Daseke, Michael J., II;Tenkorang, Mavis A. A.;Lindsey, Merry L.
心肌梗死(MI)后心脏创面的愈合从促炎到抗炎再到修复反应，心脏成纤维细胞在整个过程中起着核心作用。成纤维细胞反映了左室梗死中的变化，经历了一系列的极化表型，这些表型遵循促炎、抗炎和促瘢痕形成的特征。每种表型转变的发展取决于成纤维细胞进入的心肌梗死环境。在这篇简短的综述中，我们总结了我们目前关于心肌梗死期间心脏成纤维细胞激活的知识，并强调了仍然存在差距的关键领域。(C)2020年提交人(S)。由Elsevier B.V.出版。这是一篇CC BY-NC-ND许可证下的开放获取文章。(http://creativecommons.org/licenses/by-nc-nd/4.0/)
Cardiac wound healing after myocardial infarction (MI) evolves from pro-inflammatory to anti-inflammatory to reparative responses, and the cardiac fibroblast is a central player during the entire transition. The fibroblast mirrors changes seen in the left ventricle infarct by undergoing a continuum of polarization phenotypes that follow pro-inflammatory, anti-inflammatory, and pro-scar producing profiles. The development of each pheno-type transition is contingent upon the MI environment into which the fibroblast enters. In this mini-review, we summarize our current knowledge regarding cardiac fibroblast activation during MI and highlight key areas where gaps remain. (c) 2020 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/)