An activation of parvocellular oxytocinergic neurons in the paraventricular nucleus in oxytocin-induced yawning and penile erection
An activation of parvocellular oxytocinergic neurons in the paraventricular nucleus in oxytocin-induced yawning and penile erection
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DOI：
10.1016/j.neures.2005.12.005
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发表时间：
2006-04-01
影响因子：
2.9
通讯作者：
Nishino, S
中科院分区：
文献类型：
--
作者：
Kita, I;Yoshida, Y;Nishino, S
脑室内（ICV）或PVN局部注射催产素诱导打哈欠和阴茎勃起，PVN催产素能激活的正反馈机制被认为，但这还没有在体内得到直接证实。我们已经评估了行为的影响和催产素能神经元的活性与c-Fos和催产素的双重染色PVN后，ICV给药催产素在成年雄性大鼠。ICV催产素注射（50和200 ng）剂量依赖性地诱导打哈欠和阴茎勃起，并显著增加PVN内侧、背侧和外侧小细胞亚群中c-Fos阳性催产素神经元的百分比。然而，大细胞部分的增加并不显著。我们还发现，氯化锂（LiCl，0.5和1.0毫当量），一种已知激活催产素能神经元的化合物，也显着增加c-Fos阳性催产素神经元在所有PVN部分的百分比。但氯化锂对催产素诱发的哈欠和阴茎勃起无明显影响。这些结果表明，如果PVN中催产素能神经元的激活对于介导催产素诱导的打哈欠和阴茎勃起是重要的，则PVN中小细胞催产素能神经元的选择性激活可能参与其中。(c)2005年Elsevier爱尔兰有限公司和日本神经科学学会。所有的战斗保留。
Intracerebrovcntricular (ICV) or PVN local injections of oxytocin induce yawning and penile erection, for which a positive feedback mechanism for the PVN oxytocinergic activation is suggested, but this had not been directly substantiated in vivo. We have assessed the behavioral effects and activity of oxytocinergic neurons with double-staining for c-Fos and oxytocin in the PVN after ICV administration of oxytocin in adult male rats. ICV oxytocin injections (50 and 200 ng) dose-dependently induced yawning and penile erection and significantly increased the percentage of c-Fos positive oxytocin neurons in the medial, dorsal and lateral parvocellular subdivision of the PVN. However, increases in the magnocellular portion were not significant. We also found that lithium chloride (LiCl, 0.5 and 1.0 mEq), a compound known to activate oxytocinergic neurons, also significantly increased the percentage of c-Fos positive oxytocin neurons in all PVN portions. However, LiCl did not induce yawning and penile erection, but counteracted the oxytocin-induced yawning and penile erection. These results suggest that if the activation of oxytocinergic neurons in the PVN is important for mediating oxytocin-induced yawning and penile erection, a selective activation of parvocellular oxytocinergic neurons in the PVN is likely to be involved. (c) 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All fights reserved.