Electrical nanogap devices for biosensing
Electrical nanogap devices for biosensing
复制标题
用于生物传感的电纳米间隙器件
DOI：
10.1016/s1369-7021(10)70201-7
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发表时间：
2010-11-01
期刊：
影响因子：
24.2
通讯作者：
Huang, Xing-Jiu
中科院分区：
文献类型：
--
作者：
Chen, Xing;Guo, Zheng;Huang, Xing-Jiu
为了检测人眼或鼻子看不见的物质，特别是那些生物分子，设备必须具有非常小的特征尺寸、结构紧凑并提供足够的灵敏度，通常是针对少量尺寸仅为几纳米的生物分子。用于生物传感的电纳米间隙装置已成为检测极少量生物分子的强大技术。该设备最迷人的特点是直接将生物分子特异性结合事件转换成有用的电信号，例如电阻/阻抗、电容/介电或场效应。电生物传感中的纳米间隙器件已成为一个不断扩展的繁忙研究领域。有大量研究讨论用于生物传感的平面和垂直纳米间隙器件。平面纳米间隙器件包括无标记、金纳米颗粒标记、纳米颗粒增强、纳米间隙金颗粒膜和碳纳米管纳米间隙器件以及用于生物传感的具有两个和三个端子的垂直纳米间隙器件。本文的目的是提供该领域工作的最新概述。在每个部分中，我们讨论了电生物传感的操作原理，并考虑了提高其性能的主要策略和/或当前阶段及其进一步发展中的主要挑战和机遇。
For detecting substances that are invisible to the human eye or nose, and particularly those biomolecules, the devices must have very small feature sizes, be compact and provide a sufficient level of sensitivity, often to a small number of biomolecules that are just a few nanometres in size. Electrical nanogap devices for biosensing have emerged as a powerful technique for detecting very small quantities of biomolecules. The most charming feature of the devices is to directly transduce events of biomolecules specific binding into useful electrical signals such as resistance/impedance, capacitance/dielectric, or field-effect. Nanogap devices in electrical biosensing have become a busy area of research which is continually expanding. A wealth of research is available discussing planar and vertical nanogap devices for biosensing. Planar nanogap devices including label-free, gold nanoparticle-labeled, nanoparticles-enhanced, nanogapped gold particle film, and carbon nanotube nanogap devices as well as vertical nanogap devices with two and three terminals for biosensing are carefully reviewed. The aim of this paper is to provide an updated overview of the work in this field. In each part, we discuss the principles of operation of electrical biosensing and consider major strategies for enhancing their performance and/or key challenges and opportunities in current stages, and in their further development.