CONTRACTION OF GUINEA-PIG ILEAL SMOOTH-MUSCLE BY ACETYL GLYCERYL ETHER PHOSPHORYLCHOLINE
CONTRACTION OF GUINEA-PIG ILEAL SMOOTH-MUSCLE BY ACETYL GLYCERYL ETHER PHOSPHORYLCHOLINE
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DOI：
10.1152/ajpcell.1981.241.3.c130
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发表时间：
1981-01-01
影响因子：
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通讯作者：
PINCKARD, RN
中科院分区：
文献类型：
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作者：
FINDLAY, SR;LICHTENSTEIN, LM;PINCKARD, RN
乙酰甘油醚磷酰胆碱 (AGEPC) 是一种化学物质，具有以前称为血小板激活因子的生物活性。合成 AGEPC 诱导豚鼠回肠平滑肌收缩。组胺、乙酰胆碱和慢反应物质 (SRS) 的拮抗剂不会阻止 AGEPC 诱导的收缩。这些反应是持久的、耐洗涤的，并且表现出完全的激动剂特异性脱敏作用。组胺和 SRS 诱导的收缩不受 AGEPC 的影响。这些研究表明 AGEPC 有可能产生过敏引起的平滑肌收缩的成分。
Acetyl glyceryl ether phosphorylcholine (AGEPC) is a chemical that has the biological activity of what was formerly termed platelet-activating factor. Synthetic AGEPC induced contraction of guinea pig ileal smooth muscle. Antagonists of histamine, acetylcholine and slow-reacting substances (SRS) do not block AGEPC-induced contraction. These responses were long lasting, resistant to washing, and displayed complete agonist specific desensitization. Histamine- and SRS-induced contractions were unaffected by AGEPC. These studies show that AGEPC has the potential to produce a component of anaphylactically induced smooth muscle contraction.