Metformin versus dietary treatment in nonalcoholic hepatic steatosis: a randomized study
Metformin versus dietary treatment in nonalcoholic hepatic steatosis: a randomized study
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DOI：
10.1038/ijo.2010.40
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发表时间：
2010-08-01
影响因子：
4.9
通讯作者：
Belfiore, A.
中科院分区：
文献类型：
--
作者：
Garinis, G. A.;Fruci, B.;Belfiore, A.
Objective: We aimed at evaluating whether the addition of low-dose metformin to dietary treatment could be an effective approach in nondiabetic patients with nonalcoholic fatty liver disease (NAFLD).Methods: We carried out a 6-month prospective study in a series of overweight or obese patients with ultrasonographic diagnosis of hepatic steatosis. In total, 50 patients were enrolled and randomized into two groups: the first group (n = 25) was given metformin (1 g per day) plus dietary treatment and the second group (n = 25) was given dietary treatment alone.Results: At the end of the study, the proportion of patients with echographic evidence of fatty liver was reduced in both the metformin (P
