Evaluation of anti-fertility activity of Tabernaemontana divaricata (Linn) R.Br. leaves in rats
Evaluation of anti-fertility activity of Tabernaemontana divaricata (Linn) R.Br. leaves in rats
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DOI：
10.1080/14786410903314385
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发表时间：
2010-03
影响因子：
2.2
通讯作者：
S. Jain;Avijeet Jain;L. Deb;K. R. Dutt;D. Jain
中科院分区：
文献类型：
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作者：
S. Jain;Avijeet Jain;L. Deb;K. R. Dutt;D. Jain
本研究的目的是评估的乙醇提取物Tabernaemontana divaricata（TD）叶的抗生育活性在雌激素活性模型在未成年雌性大鼠。收集TD的成熟绿色叶并进行鉴定。在索氏装置中用乙醇进行干燥叶的提取。对于雌激素活性，提取物以200和400 mg kg−1的剂量每日一次口服给药，并将活性与标准药物炔雌醇（0.02 mg）进行比较。与对照组相比，浸提液导致子宫重量显著增加。乙醇提取物具有雌激素活性。与200 mg TD浸提液给药组动物相比，400 mg TD浸提液给药组动物的上皮组织学研究显示腔上皮高度增加，水肿基质疏松。然而，这比对照组的动物好。增强子宫重量和增加的高度腔上皮和组织学特征表明，TD提取物可能是有用的抗生育治疗。
The aim of the present study was to assess the anti-fertility activity of ethanolic extracts of Tabernaemontana divaricata (TD) leaves in oestrogenic activity models in immature female rats. Mature green leaves of TD were collected and authenticated. Extractions of the dried leaves were carried out with ethanol in a Soxhlet's apparatus. For oestrogenic activity, the extracts were administered orally once daily at a dose of 200 and 400 mg kg−1, and the activity was compared with the standard drug ethinyl oestradiol (0.02 mg). The extracts caused significant increase in uterine weight compared to the control. The ethanolic extract exhibited oestrogenic activity. The histological study of epithelium tissues with the 400 mg of TD extract-treated animals showed increases in the height of the luminal epithelium and loose edematous stroma when compared with the 200 mg of TD extract-treated group of animals. However, this was better than the control group of animals. Enhanced uterine weight and increase in the height of luminal epithelium and histological characteristics suggest that TD extract may be useful in anti-fertility therapy.