Cannabidiol prevents the development of cold and mechanical allodynia in paclitaxel-treated female C57Bl6 mice.
Cannabidiol prevents the development of cold and mechanical allodynia in paclitaxel-treated female C57Bl6 mice.
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DOI：
10.1213/ane.0b013e3182283486
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发表时间：
2011-10
影响因子：
5.7
通讯作者：
Walker EA
中科院分区：
文献类型：
--
作者：
Ward SJ;Ramirez MD;Neelakantan H;Walker EA
紫杉烷化疗药物紫杉醇经常导致人类周围神经病变。研究机制和治疗方法的啮齿动物模型在很大程度上仅限于雄性大鼠，而雌性小鼠则缺乏研究。我们研究了不同剂量的紫杉醇对雄性和雌性C57BL/6小鼠寒冷性和机械性痛觉过敏的治疗作用。因为非心理活性的植物大麻素大麻二醇可以减轻其他形式的神经病理性疼痛，所以我们评估了它对紫杉醇诱导的痛觉异常的影响。紫杉醇在雌性小鼠身上产生的痛觉异常在很大程度上是剂量依赖性的，而且更强烈，这种影响可以通过大麻二醇治疗来阻止。因此，我们的初步发现表明，大麻二醇可以防止紫杉醇诱导的小鼠痛觉异常的发展，因此在预防剂量限制的紫杉醇诱导的人类周围神经病方面是有效的。
The taxane chemotherapeutic paclitaxel frequently produces peripheral neuropathy in humans. Rodent models to investigate mechanisms and treatments are largely restricted to male rats, whereas female mouse studies are lacking. We characterized a range of paclitaxel doses on cold and mechanical allodynia in male and female C57Bl/6 mice. Because the nonpsycho-active phytocannabinoid cannabidiol attenuates other forms of neuropathic pain, we assessed its effect on paclitaxel-induced allodynia. Paclitaxel produced allodynia that was largely dose independent and more robust in female mice, and this effect was prevented by treatment with cannabidiol. Our preliminary findings therefore indicate that cannabidiol may prevent the development of paclitaxel-induced allodynia in mice and therefore be effective at preventing dose-limiting paclitaxel-induced peripheral neuropathy in humans.