A role for leptin in brain development
A role for leptin in brain development
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DOI：
10.1006/bbrc.1999.0382
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发表时间：
1999-03-24
影响因子：
3.1
通讯作者：
Swick, AG
中科院分区：
文献类型：
--
作者：
Steppan, CM;Swick, AG
瘦素是肥胖基因的产物，是一种参与摄食行为和能量稳态的循环激素。瘦素缺乏的 Ob/ob 小鼠有许多表型异常，包括大脑重量和皮质体积较小。为此，我们监测了瘦素给药对大脑生长的影响。每天对 4 周大的 ob/ob 小鼠腹膜内注射瘦素 2 周，导致脑干重和湿重最大增加 10%。这种增加似乎部分是由于细胞数量增加所致，大脑 DNA 总量增加了 19%。总之，我们的数据表明，ob/ob 小鼠大脑尺寸的减小是由于发育缺陷造成的，这种缺陷可以通过瘦素给药来纠正，因此瘦素在大脑生长和发育中发挥着作用。 (C) 1999 年学术出版社。
Leptin,the product of the obese gene, is a circulating hormone involved in feeding behavior and energy homeostasis. Ob/ob mice which are leptin deficient have many phenotypic abnormalities including brains that are smaller in both weight and cortical volume. To this end, we monitored the effects of leptin administration on brain growth. Intraperitoneal administration of leptin for 2 weeks daily to 4-week-old ob/ob mice resulted in a maximal 10% increase in both wet and dry brain weights. This increase appears to be partially the result of increased cell number as indicated by a 19% increase in total brain DNA. In summary, our data suggest that the decreased brain size-of the ob/ob mouse is due to a developmental defect that can be corrected upon leptin administration and therefore leptin plays a role in brain growth and development. (C) 1999 Academic Press.