Examining racial differences in diffuse large B-cell lymphoma presentation and survival.
Examining racial differences in diffuse large B-cell lymphoma presentation and survival.
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DOI：
10.3109/10428194.2012.708751
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发表时间：
2013-02
影响因子：
2.6
通讯作者：
Foran J
中科院分区：
文献类型：
--
作者：
Flowers CR;Shenoy PJ;Borate U;Bumpers K;Douglas-Holland T;King N;Brawley OW;Lipscomb J;Lechowicz MJ;Sinha R;Grover RS;Bernal-Mizrachi L;Kowalski J;Donnellan W;The A;Reddy V;Jaye DL;Foran J
我们对1981-2010年间在美国南部两个转诊中心接受治疗的701例DLBCL患者（533例白色和144例黑人）进行了回顾性队列分析。黑人诊断的中位年龄为50岁，白人为57岁（p<0.001）。出现乳酸脱氢酶水平升高、B症状和体能状态≥2的黑人百分比更高。白人（8%）比黑人（3%）有淋巴瘤阳性家族史（p=0.048）。R-CHOP的使用无种族差异（52%黑人vs. 47%白色，p=0.73）。虽然黑人种族预测接受CHOP治疗的患者的生存率较低（风险比[HR] 1.8，p<0.001），但接受R-CHOP治疗的患者的生存率与种族无关（HR 0.61，p=0.01）。未来的研究应该检查可能构成所观察到的表现和结果种族差异的生物学差异。
We performed a retrospective cohort analysis of 701 (533 White and 144 Black) patients with DLBCL treated at two referral centers in southern United States between 1981-2010. Median age of diagnosis for Blacks was 50 years vs. 57 years for Whites (p<0.001). A greater percentage of Blacks presented with elevated lactate dehydrogenase levels, B-symptoms, and performance status≥2. More Whites (8%) than Blacks (3%) had positive family history of lymphoma (p=0.048). There were no racial differences in the use of R-CHOP (52% Black vs. 47% White, p=0.73). While black race predicted worse survival among patients treated with CHOP (Hazard ratio [HR] 1.8, p<0.001), treatment with R-CHOP was associated with improved survival irrespective of race (HR 0.61, p=0.01). Future studies should examine biological differences that may underlie the observed racial differences in presentation and outcome.
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Alacacioglu, Inci;Ozcan, Mehmet Ali;Undar, Bulent
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