Assessment of corneal epithelial thickness in dry eye patients.
Assessment of corneal epithelial thickness in dry eye patients.
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干眼症患者角膜上皮厚度的评估
DOI：
10.1097/opx.0000000000000417
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Xu J
中科院分区：
文献类型：
--
作者：
Cui X;Hong J;Wang F;Deng SX;Yang Y;Zhu X;Wu D;Zhao Y;Xu J
目的探讨干眼症患者角膜上皮厚度地形图的傅里叶域光学相干断层扫描（OCT）特征。在这项横断面研究中，纳入了 100 名有症状的干眼患者和 35 名正常受试者。所有参与者均回答了眼表疾病指数问卷，并接受 OCT、角膜荧光素染色、泪液破裂时间、无麻醉 Schirmer 1 测试 (S1t) 和睑板形态学检查。对每只眼睛的几个上皮统计数据进行平均，包括中央、上、下、最小值、最大值、最小值-最大值和图谱标准差。计算上皮厚度与干眼症状的相关性。正常眼的中央、上、下角膜上皮厚度平均（±SD）分别为53.57（±3.31）μm、52.00（±3.39）μm和53.03（±3.67）μm，而正常眼的平均（±SD）中央、上、下角膜上皮厚度分别为52.71（±2.83）μm、50.58（±3.44）μm和52.53（±3.36）μm。干眼中分别为μm。与正常人相比，干眼症患者的上角膜上皮较薄（p=0.037），而中央上皮和下上皮则无统计学差异。在干眼组中，严重程度较高的患者上皮厚度较薄（p = 0.017）和最小（p < 0.001），范围更宽（p = 0.032），偏差更大（p = 0.003）。平均中央上皮厚度与泪液破裂时间、S1t 或睑板腺的严重程度没有相关性，而平均上皮厚度与 S1t 呈正相关（r = 0.238，p = 0.017）。傅里叶域 OCT 表明，干眼角膜上皮的厚度图比正常眼睛的上部区域更薄。在更严重的干眼病患者中，上皮和最小上皮更薄，图谱标准偏差范围更大。
To investigate the features of corneal epithelial thickness topography with Fourier-domain optical coherence tomography (OCT) in dry eye patients. In this cross-sectional study, 100 symptomatic dry eye patients and 35 normal subjects were enrolled. All participants answered the ocular surface disease index questionnaire and were subjected to OCT, corneal fluorescein staining, tear breakup time, Schirmer 1 test without anesthetic (S1t), and meibomian morphology. Several epithelium statistics for each eye, including central, superior, inferior, minimum, maximum, minimum – maximum, and map standard deviation, were averaged. Correlations of epithelial thickness with the symptoms of dry eye were calculated. The mean (±SD) central, superior, and inferior corneal epithelial thickness was 53.57 (±3.31) μm, 52.00 (±3.39) μm, and 53.03 (±3.67) μm in normal eyes and 52.71 (±2.83) μm, 50.58 (±3.44) μm, and 52.53 (±3.36) μm in dry eyes, respectively. The superior corneal epithelium was thinner in dry eye patients compared with normal subjects (p=0.037),whereas central and inferior epithelium were not statistically different. In the dry eye group, patients with higher severity grades had thinner superior (p = 0.017) and minimum (p < 0.001) epithelial thickness, more wide range (p = 0.032), and greater deviation (p = 0.003). The average central epithelial thickness had no correlation with tear breakup time, S1t, or the severity of meibomian glands, whereas average superior epithelial thickness positively correlated with S1t (r = 0.238, p = 0.017). Fourier-domain OCT demonstrated that the thickness map of the dry eye corneal epithelium was thinner than normal eyes in the superior region. In more severe dry eye disease patients, the superior and minimum epithelium was much thinner, with a greater range of map standard deviation.