Glucocorticoids in the prefrontal cortex enhance memory consolidation and impair working memory by a common neural mechanism
Glucocorticoids in the prefrontal cortex enhance memory consolidation and impair working memory by a common neural mechanism
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DOI：
10.1073/pnas.1011975107
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发表时间：
2010-09-21
影响因子：
11.1
通讯作者：
Roozendaal, Benno
中科院分区：
文献类型：
--
作者：
Barsegyan, Areg;Mackenzie, Scott M.;Roozendaal, Benno
众所周知，肾上腺皮质激素的急性给药增强了情感经历记忆的巩固，同时损害了工作记忆。糖皮质激素对这两种记忆功能的不同影响通常被认为是独立调节的过程。在这里，我们报告说，糖皮质激素受体激动剂管理到内侧前额叶皮层（mPFC）的雄性Sprague-Dawley大鼠既增强记忆巩固和损害工作记忆。这两种记忆效应都是通过激活膜结合的类固醇受体介导的，并依赖于mPFC内的去甲肾上腺素能活性，以增加cAMP依赖性蛋白激酶的水平。这些发现提供了直接的证据表明，糖皮质激素对记忆巩固和工作记忆的作用在mPFC中具有共同的神经影响。
It is well established that acute administration of adrenocortical hormones enhances the consolidation of memories of emotional experiences and, concurrently, impairs working memory. These different glucocorticoid effects on these two memory functions have generally been considered to be independently regulated processes. Here we report that a glucocorticoid receptor agonist administered into the medial prefrontal cortex (mPFC) of male Sprague-Dawley rats both enhances memory consolidation and impairs working memory. Both memory effects are mediated by activation of a membrane-bound steroid receptor and depend on noradrenergic activity within the mPFC to increase levels of cAMP-dependent protein kinase. These findings provide direct evidence that glucocorticoid effects on both memory consolidation and working memory share a common neural influence within the mPFC.