The effects of unilateral discectomy and condylectomy on the contralateral intact rabbit craniomandibular joint
The effects of unilateral discectomy and condylectomy on the contralateral intact rabbit craniomandibular joint
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DOI：
10.1016/j.joms.2006.04.023
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发表时间：
2006-08-01
影响因子：
1.9
通讯作者：
Slavin, John
中科院分区：
文献类型：
--
作者：
Dimitroulis, George;Slavin, John
目的：本研究旨在从组织学水平探讨单侧椎间盘切除和髁突切除对健侧完整兔颅下颌关节的影响。材料与方法：新西兰白色兔15只，分为3组。3只家兔作为对照组（A组），其中进行假手术而不破坏左颅下颌关节（CMJ）的关节间隙。B组6只，切除左侧CMJ关节盘。其余6只（Q组）在髁颈水平切除左侧髁突头。所产生的手术缺损在没有任何移植物的情况下愈合，并用可吸收缝线闭合切口。手术后4周、12周和20周处死兔，对左、右CMJ进行组织学制备，并在光学显微镜下进行检查。结果：在4周组中，单侧椎间盘切除术和髁状突切除术导致未手术的右CMJ重塑，髁状突头部扁平化的组织学证据在髁状突切除术组中更为明显。在12周组中，未手术的右侧CMJ的重塑过程不太明显，大部分活动集中在内侧极，尤其是在髁状突切除组中。20周组在椎间盘切除术和髁状突切除术组中未手术的右侧CMJ中没有明显的重塑迹象。在所有组中，在接受髁状突切除术的左侧CMJ中均观察到髁状突再生的证据。没有证据表明，在任何的discectomy groups.Conclusions：单侧椎间盘切除术和髁状突切除术的结构完整性的对侧未操作CMJ，这似乎是短暂的早期不良影响的光盘再生。未手术的右侧CMJ的早期重塑效应似乎是可逆的，因为手术的左侧CMJ愈合。(C)2006年美国口腔颌面外科医师协会。
Purpose: The purpose of this study is to determine the effects of unilateral discectomy and condylectomv on the contralateral intact rabbit craniomandibular joint at the histological level.Materials and Methods: Fifteen New Zealand white rabbits were used and divided into 3 groups. Three rabbits were used as controls (group A) whereby a sham operation was undertaken without breaching the joint space of the left craniomandibular joint (CMJ). In 6 rabbits (group B), the articular disc of the left CMJ was excised. The remaining 6 rabbits (group Q underwent surgical resection of the left condylar head at the level of the condylar neck. The resultant surgical defects were left to heal without any grafting and the incisions were closed with resorbable sutures. The rabbits were sacrificed at 4, 12, and 20 weeks after surgery and both the left and right CMJs were histologically prepared and examined under light microscopy.Results: in the 4-week group, unilateral discectomy and condylectomy resulted in remodeling of the unoperated right CMJ with histological evidence of flattening of the condylar head which was more pronounced in the condylectomy group. In the 12-week group, the remodeling process in the unoperated right CMJ was less pronounced with most of the activity concentrated in the medial pole, especially in the condylectomy group. The 20-week group showed no obvious signs of remodeling in the unoperated right CMJs in both the discectomy and condylectomy groups. Evidence of condylar regeneration was seen in all groups in the left CMJ which had undergone condylectomy. No evidence of disc regeneration in the operated left CMJ was seen in any of the discectomy groups.Conclusions: Unilateral discectomy and condylectomy have an early adverse effect on the structural integrity of the contralateral unoperated CMJ which appears to be short lived. The early remodeling effects on the unoperated right CMJ appear to be reversible as the operated left CMJ heals. (C) 2006 American Association of Oral and Maxillofacial Surgeons.